Volume 1402, Issue 4 (12-2023)
2023, 1402(4): 0-0 |
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Ethics code: IR.MEDILAM.REC.1397.056
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Basati G, Bastaminejad S, IzadiAjeerlo B. Evaluation of the Gas2 gene expression change in colorectal adenocarcinoma tumors in comparison to normal adjacent tissue and its relation to disease prognosis. Journal title 2023; 1402 (4)
URL: http://newresearch.medilam.ac.ir/article-1-2627-en.html
URL: http://newresearch.medilam.ac.ir/article-1-2627-en.html
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical sciences, Ilam, Iran
Abstract: (390 Views)
Background: Growth arrest-specific 2 (GAS2) is implicated in a variety of cellularfunctions such as cell cycle, apoptosis and proliferation and may be potentially involved in cancer progression.However, whether GAS2 is associated with colorectal cancer (CRC) progression and prognosis remains to be uncovered. Thus, this study investigated the association of GAS2 expression in tumor with CRC progression and prognosis.
Methods:In the case-control study, surgical tumor and adjacent normal tissues from 40 CRC patients were prospectively collected at Institute Cancer of Imam Khomeini Hospital in Tehran and relative expression level of GAS2 in the tissues was assayed using quantitative real-time polymerase chain reaction method. The correlation of tumor GAS2 expression with the clinicopathological features and overall survival rate of patients was determined.
Findings: The relative expression level of GAS2 in tumor tissues was significantly elevated compared to the adjacent normal tissues [1.96(1.17-3.40) vs. 1.10(1.00-1.31), P=0.00001]. Moreover, the expression levels of GAS2 in the tumor tissues were significantly associated with clinicopathological features of cancer including tumor TNM stages, grade, size, lymphatic and vascular invasion as well as the decreased overall survival (P=0.01, P=0.01,
P=0.03, P=0.03, P=0.04, and P=0.04, respectively).
Conclusion: Elevated expression of GAS2 in CRC is associated with the cancer progression indices and poor prognosis, hence it may serve as a prognostic biomarker in CRC.
Methods:In the case-control study, surgical tumor and adjacent normal tissues from 40 CRC patients were prospectively collected at Institute Cancer of Imam Khomeini Hospital in Tehran and relative expression level of GAS2 in the tissues was assayed using quantitative real-time polymerase chain reaction method. The correlation of tumor GAS2 expression with the clinicopathological features and overall survival rate of patients was determined.
Findings: The relative expression level of GAS2 in tumor tissues was significantly elevated compared to the adjacent normal tissues [1.96(1.17-3.40) vs. 1.10(1.00-1.31), P=0.00001]. Moreover, the expression levels of GAS2 in the tumor tissues were significantly associated with clinicopathological features of cancer including tumor TNM stages, grade, size, lymphatic and vascular invasion as well as the decreased overall survival (P=0.01, P=0.01,
P=0.03, P=0.03, P=0.04, and P=0.04, respectively).
Conclusion: Elevated expression of GAS2 in CRC is associated with the cancer progression indices and poor prognosis, hence it may serve as a prognostic biomarker in CRC.
Received: 2024/01/13 | Accepted: 2023/12/31 | Published: 2023/12/31
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