Volume 1402, Issue 4 (12-2023)
2023, 1402(4): 0-0 |
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Ethics code: IR.MEDILAM.REC1397.149
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Maleki M, Salimi A H, Kafashian M, Parvari S, Ghanei Alvar H, Abbasi N, et al . Protective effects of pretreatment or concomitant treatment with Hypericum extract on renal function and renal toxicity in cisplatin-induced nephrotoxicity. Journal title 2023; 1402 (4)
URL: http://newresearch.medilam.ac.ir/article-1-2500-en.html
URL: http://newresearch.medilam.ac.ir/article-1-2500-en.html
Maryam Maleki 
, Amir Hossein Salimi , Mohamadreza Kafashian , Shams Parvari , Hori Ghanei Alvar , Naser Abbasi , Azra Kenarkoohi , Nastaran Afsordeh , Neda Moulaei
, Amir Hossein Salimi , Mohamadreza Kafashian , Shams Parvari , Hori Ghanei Alvar , Naser Abbasi , Azra Kenarkoohi , Nastaran Afsordeh , Neda Moulaei
Department of Physiology, School of Medicine, Ilam University of Medical sciences, Ilam, Iran
Abstract: (493 Views)
Cisplatin is an anticancer drug, whose full name is (CDDP) cis-diamminedichloroplatinum. In practice, cisplatin is the same as alkylating drugs that destroys cells at all stages of the cell cycle by forming cross-links between DNA chains and inhibiting their synthesis, and also leads to tissue damage by producing oxidant substances. This drug has great value in the clinic because its antitumor activity is strong and it is especially used in the treatment of advanced cancers and malignant tumors. Despite its therapeutic effects, cisplatin has many side effects. Among the most important side effects of this drug is nephrotoxicity (kidney poisoning) and its use is limited due to the many side effects it leaves on different organs, especially the kidneys.
Accumulation of cisplatin in kidney is more than other organs and kidney is considered as the main organ for its elimination. This substance appears in glomerular filters through glomerular filtration and the reabsorption process does not take place on it. The use of cisplatin leads to an increase in the level of creatinine, blood urea nitrogen (BUN), and also causes acute cell necrosis in the renal tubules, especially the proximal convoluted tubules, as well as cell apoptosis and interstitial tissue damage in the form of edematous processes, which ultimately leads to a decrease in filtration. glomeruli and the occurrence of acute renal toxicity. Several factors such as reactive oxygen species (ROS), synthesis of cytokines and chemokines are involved in the pathology of kidney injuries. Treatment with CDDP increases the level of malondialdehyde (MDA) and decreases renal glutathione (GSH), while antioxidant agents decrease the level of MDA and increase GSH, and also prevent the increase of chromium caused by CDDP.
CDDP also decreases the activity of catalase, superoxide dismutase (SOD) and glutathione peroxidase Antioxidant treatments may compensate for it. Observations have shown that nephrotoxicity is caused by different oxygen radicals such as superoxide anion, hydrogen peroxide and hydroxyl. On the other hand, phenolic components and especially flavonoids are powerful sources of antioxidants. Many plants contain flavonoids.
Hypericum plant has been reported to have neuroprotective and antioxidant effects. Hypericum contains bioactive components such as hypericin, hyperphorin, flavonoids, xanthan and biapigenin derivatives. This plant has antioxidant and anti-inflammatory effects in intestinal or liver ischemia disorders. A study on the protective effects of pretreatment with hypericum extract (or as a simultaneous use) in nephrotoxicity caused by cisplatin is not available.
Accumulation of cisplatin in kidney is more than other organs and kidney is considered as the main organ for its elimination. This substance appears in glomerular filters through glomerular filtration and the reabsorption process does not take place on it. The use of cisplatin leads to an increase in the level of creatinine, blood urea nitrogen (BUN), and also causes acute cell necrosis in the renal tubules, especially the proximal convoluted tubules, as well as cell apoptosis and interstitial tissue damage in the form of edematous processes, which ultimately leads to a decrease in filtration. glomeruli and the occurrence of acute renal toxicity. Several factors such as reactive oxygen species (ROS), synthesis of cytokines and chemokines are involved in the pathology of kidney injuries. Treatment with CDDP increases the level of malondialdehyde (MDA) and decreases renal glutathione (GSH), while antioxidant agents decrease the level of MDA and increase GSH, and also prevent the increase of chromium caused by CDDP.
CDDP also decreases the activity of catalase, superoxide dismutase (SOD) and glutathione peroxidase Antioxidant treatments may compensate for it. Observations have shown that nephrotoxicity is caused by different oxygen radicals such as superoxide anion, hydrogen peroxide and hydroxyl. On the other hand, phenolic components and especially flavonoids are powerful sources of antioxidants. Many plants contain flavonoids.
Hypericum plant has been reported to have neuroprotective and antioxidant effects. Hypericum contains bioactive components such as hypericin, hyperphorin, flavonoids, xanthan and biapigenin derivatives. This plant has antioxidant and anti-inflammatory effects in intestinal or liver ischemia disorders. A study on the protective effects of pretreatment with hypericum extract (or as a simultaneous use) in nephrotoxicity caused by cisplatin is not available.
Received: 2023/09/4 | Accepted: 2023/09/4 | Published: 2023/12/31
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