Volume 1402, Issue 1 (5-2023)
2023, 1402(1): 0-0 |
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Ethics code: IR.MEDILAM.REC.1399.171
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Noorimotlagh Z, Mirzaee S A, Maleki M, Kafashian M. Investigating the Relationship between Pregnant Mothers' Environmental Exposure to Pesticides and Autism Disorders in Children: A Systematic Review Study. Journal title 2023; 1402 (1)
URL: http://newresearch.medilam.ac.ir/article-1-829-en.html
URL: http://newresearch.medilam.ac.ir/article-1-829-en.html
Psychosocial Injuries Research Center, Ilam University of Medical sciences, Ilam, Iran
Abstract: (701 Views)
Age and developmental stages affect the rate of the susceptibility to neurotoxic hurt; and early development is especially high susceptible. Science has come to the fact: early encounter with neurotoxins, during neurodevelopment, can dramatically change some processes consisting cell division/proliferation, cell migration/differentiation, synaptic formation, and apoptosis. Based on studies etiology of ASD can be genetic and environmental, factors (heavy metals and pesticides) and lifestyle play as key role in development of the disease, as maternal residency near to the place of applying pesticides for agricultural purposes during determined gestation time could be related with ASD among their relevant children.
There are some evidences that ASD risk increases in offspring following prenatal exposure to common agricultural and environmental pesticides in pregnant mother’s residency, against offspring of women from the same region without this exposure. It was stated that the ASD risk is associated with prenatal exposure to glyphosate, chlorpyrifos, diazinon, malathion, avermectin, and permethrin. By agricultural aims, applying the most common pesticides near residencies (organophosphates and pyrethroids) might enhance the ASD prevalence. Positive associations between ASD occurrence and proximity of prenatal residency to organophosphate pesticides in the second (for chlorpyrifos) and third trimesters (organophosphates), and pyrethroids in the 3 months before conception and in the third trimester were reported.
Products of combustion, or exhaust, have some chemicals (polyaromatic hydrocarbons) and particulate matter. Polyaromatic hydrocarbons may increase endocrine and immune system disrupting potential, as mentioned is implicated in the ASD etiology. Particulate matter from air pollution may lead to increased inflammatory genes expression consequently increased systemic inflammation and oxidative stress. Inconsistent with these some research has shown an upper risk of ASD related to the proximity of prenatal residency to freeways or region with high-level airborne diesel exhaust . Exposing to air pollution and traffic might lead to some pregnancy outcomes related to ASD recognized as important to test for ASD etiology.
There are some evidences that ASD risk increases in offspring following prenatal exposure to common agricultural and environmental pesticides in pregnant mother’s residency, against offspring of women from the same region without this exposure. It was stated that the ASD risk is associated with prenatal exposure to glyphosate, chlorpyrifos, diazinon, malathion, avermectin, and permethrin. By agricultural aims, applying the most common pesticides near residencies (organophosphates and pyrethroids) might enhance the ASD prevalence. Positive associations between ASD occurrence and proximity of prenatal residency to organophosphate pesticides in the second (for chlorpyrifos) and third trimesters (organophosphates), and pyrethroids in the 3 months before conception and in the third trimester were reported.
Products of combustion, or exhaust, have some chemicals (polyaromatic hydrocarbons) and particulate matter. Polyaromatic hydrocarbons may increase endocrine and immune system disrupting potential, as mentioned is implicated in the ASD etiology. Particulate matter from air pollution may lead to increased inflammatory genes expression consequently increased systemic inflammation and oxidative stress. Inconsistent with these some research has shown an upper risk of ASD related to the proximity of prenatal residency to freeways or region with high-level airborne diesel exhaust . Exposing to air pollution and traffic might lead to some pregnancy outcomes related to ASD recognized as important to test for ASD etiology.
Received: 2020/02/22 | Accepted: 2022/05/31 | Published: 2023/05/31
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