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Organ and tissue defects due to injury, illness, congenital problems and aging or any other accident have led to global health problems. Current treatments include medication, surgery, and transplantation to treat such health problems. Satisfaction with these practices is often low due to poor graft quality, graft rejection, immunological problems, tissue restriction for grafting, and so on. Repairing and repairing damaged organs with tissue engineering tools is a powerful and alternative way to repair damaged organs. The tissue engineering approach combines the disciplines of biomedical engineering and the principles of life sciences to replace, facilitate and re-establish the functional environment of the cell to repair damaged tissue. Cell-filled cells mimic the natural environment of tissue. Meanwhile, biopolymer scaffolds have been well documented and much research has led to the development of the use of these new tools in the field of tissue engineering. Biopolymer scaffolds provide a set of high-quality, well-sized three-dimensional structures for adhesion, growth, and cell proliferation. Biomaterial-based scaffolds can be prepared with different combinations of biomaterials. A combination of two or three polymers such as silk fibrin / gelatin, silk fibrin / collagen and cellulose coated with gabapentin / gelatin / bacterial cellulose have been used to regenerate damaged cartilage, bone tissue and blood vessels. Recent strategies emphasize that the synthesis of a suitable scaffold should be based on the ability to transfer biologically active compounds to improve the bone repair process. The combination of plant extracts in synthetic scaffolds is very important today that can accelerate the process of repair and regeneration of damaged tissues. There have been numerous reports of scaffolding being made with plant extracts that have been successfully made by electrospin techniques with many extracts such as grape seed extract, baicalein (Chinese plant extract), sage plant, aloe vera, and more. Plant scaffolds have several advantages such as increasing the stability of the drug, ensuring continuous release of the drug that makes the drug available to the tissue in the long run, accelerating wound healing, tissue regeneration and maximum bioavailability of the drug at the site of action. For this purpose, the aim of this study was to synthesize a chitosan-alginate scaffold combined with barberry extract to improve the process of differentiation of mesenchymal stem cells into bone cells. 

Keywords: Cell differentiation, bone marrow, scaffold, chitosan, alginate, barberry, berberine

     

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