2026-10-17T10:39:04+03:30 http://newresearch.medilam.ac.ir/browse.php?mag_id=17&slc_lang=fa&sid=1

17-1871 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 javad zabihirad rad2745@yahoo.com Hamazeh zangana hamzeh.za@gmail.com amin karimi amin.karimy@yahoo.com lila havasi lilahavase@yahoo.com سالمندی مهم ترین پدیده مردم شناختی اواخر قرن بیستم و شروع قرن بیست و یکم می باشد.  بر اساس تعریفی که افراد بالای 65 سال را سالمند محسوب می‌کند، سالمندی در حال حاضر دارای رشد 4/2 درصد در مقایسه با 7/1 درصد برای کل جمعیت می‌باشد و انتظار می‌رود که این رشد به 1/3 درصد در سال‌های آتی افزایش پیدا کند. جمعیت سالمندان از 600 میلیون در سال 2000 به یک میلیارد و دویست میلیون یعنی دو برابر در سال 2025 خواهد رسید (1). سلامتی حق اساسی هر انسان و یک هدف اجتماعی است و تمام دولت‌ها و حکومت‌ها موظف به تأمین سلامت افراد می‌باشند (2). تغییر در الگوی بیماری‌ها که کاهش میزان بیماری‌های عفونی و افزایش طول عمر و بیماری‌های مزمن را به همراه داشته، منجر به افزایش توجه به مفاهیم سلامتی و کیفیت زندگی طی دهه‌های گذشته گردیده است (3). چالش عمده واصلی بهداشت قرن بیستم افزایش امید به زندگی بود ولی چالش عمده قرن بیست و کیم، زندگی با کیفیت بهتراست. گرچه پیر شدن جمعیت از نتایج مثبت توسعه به شمار می‌آید ولی اگر برای مواجهه با آن درجهانی توسعه یافته آماده نباشیم اقتصادی و عدم کفایت خدمات اجتماعی، مراقبت‌های پزشکی و... سبب گردیده تا این قشر از آسیب‌پذیرترین اقشار جامعه باشند . ازاین‌رو توجه به کیفیت زندگی سالمندان و برنامه‌ریزی جهت ارتقاء کیفیت زندگی آنان ضروری است (4). بیماری‌های مختلفی چون سکته مغزی، دمانس و ضربه‌مغزی می‌تواند منجر به اختلالات شناختی شود.  وجود اختلالات شناختی جدی نه‌تنها باعث کاهش عملکرد شناختی فردی می‌گردد بلکه رفته‌رفته باعث احساس افسردگی و انزوای اجتماعی می‌گردد و فشار روانی فراوانی بر سالمندان و خانواده او وارد می‌کند (5). بسیاری از سالمندان به بیماری‌هایی مبتلا می‌شوند که ممکن است استقلال و کیفیت زندگی آنان را تهدید نماید. به‌طورکلی اگر سالمندان بیاموزند که چگونه باید باقیمانده عمر خود را در آرامش و آسایش بگذرانند، می‌توانند عوامل کاهش‌دهنده‌ی کیفیت زندگی خود را به نحو مطلوب تری متعادل سازند (6). اهمیت کیفیت زندگی و وضعیت سلامت تا حدی است که صاحب‌نظران معتقدند که بیشتر مراقبت‌های بهداشتی قرن حاضر بایستی بر بهبود کیفیت زندگی و وضعیت سلامت متمرکز گردد (7) کیفیت زندگی یک رویکرد معتبر برای گسترش تعریف سلامتی فراهم کرده به طوری که حوزه‌های سلامت جسمی، روانی و رفاه اجتماعی را نیز دربرمی گیرد (8) بنا به تعریف سازمان جهانی بهداشت، کیفیت زندگی درک افراد از موقعیت خود در زندگی ازنظر فرهنگ، سیستم ارزشی که در آن زندگی می‌کنند، بنابراین با نظر داشتن نیازهای خاص دوران سالمندی توجه به کیفیت زندگی سالمندان امری بسیار ضروری است (9). طرح ادغام یافته سلامت سالمندان یکی از طرح‌های بهداشتی است که از سوی وزارت بهداشت در حال اجرا است لذا بررسی تأثیر این طرح بر کیفیت زندگی سالمندان شهرستان ملکشاهی ضروری به نظر می‌رسد Quality of Life 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1871-en.docx

17-1169 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Zahra byatipur zbayati1164@gmail.com Iraj Pakzad pakzad_i2006@yahoo.com Nourkhoda Sadeghifard sadeghifard@gmail.com Ali Khorshidi ali_482002@yahoo.com Biofilm formation causes many serious problems in the treatment in infections disease. In addition, bacterial biofilms in hospitals cause contamination and great damage to the health system. Hence, the purpose of the available study was to investigate antibacterial effect of chlorhexidine (CHX) and hydrogen peroxide (H2O2) on gene expression in Enterococcus faecalis biofilm. Biofilm Chlorhexidine gluconate Hydrogen peroxide E.faecalis Asa1 efaA epaI esp qReal Time PCR 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1169-en.docx

17-670 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 javad zabihirad rad2745@yahoo.com Khairollah Asadolahi masoud_1241@yahoo.co.uk Yousef Veisani yousefveisani@gmail.com Khalil Momeni khalilmomeni1365@gmail.com direct and indirect costs diabetes Ilam 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-670-en.docx

17-540 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 maryam Deldar ma.deldarf@gmail.com Kourosh Sayehmiri sayehmiri-k@medilam.ac.ir robab anbiaee anbiaee@gmail.com Anahita Jalilian dr_anahita547@yahoo.com Background and Aim: Predicting survival time has many effective consequences in managing the quality of life for the rest of the patientchr('39')s life. On the other hand, survival data are highly variable and make accurate predictions difficult. Random survival forests by repeating tree construction and averaging the results of these trees cause reducing the prediction error and further generalizability of these results. This thesis compares the prediction error of the random survival forest model with the Cox and Weibull models in predicting the time to the first recurrence in patients with epithelial ovarian cancer. Materials and Methods: In this study, the data of 141 patients with ovarian cancer who referred to Imam Hossein Hospital in Tehran from 2008 to the end of 2018 were used. Cox regression, Weibull model, classification and regression tree, and random survival forest were fitted to the data to investigate the factors affecting the first recurrence of patients, respectively. Finally, using the C-Index and Brier score, the prediction error of these models were compared. Results: According to the results of random survival forest, metastatic tumor using the criterion (VIMP), with relative importance of 2.665 and minimal depth (MD) 2.349, tumor stage with relative importance of 1.993 and depth of 2.678, and maximum platelet count with relative importance of 2.132 and depth of 2.683 were effective variables. According to the Brier score, the random survival forest prediction error was 0.16 and the Cox model was 0.24. The C-Index error in the random survival forest was 0.34 and the Cox model was 0.42. Brier scores for the Cox and Weibull models were calculated to be approximately the same, so the random survival forest prediction error of the less than both Cox and Weibull models. Conclusion: Unlike classical methods, the random survival forest without the need for special presuppositions with less predictive error can well explain the variables of the response variable when exposed to high-dimensional data. ovarian cancer random survival forest parametric methods relapse 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-540-en.docx

17-465 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Asad Mirzaei amirzaeii@yahoo.com zohreh khorshidvand z.sunvand@gmail.com     اﻧﮕﻠﻬﺎ یﮑﯽ از ﻣﻬﻤﺘﺮیﻦ ﻋﻮاﻣﻞ ایﺠﺎدﮐﻨﻨﺪه ﺑﯿﻤﺎریﻬﺎی ﻋﻔﻮﻧﯽ در اﻓﺮاد دچار نقص سیستم ایﻤﻨﯽ هستند. اﻓﺮاد ﺗﺤﺖ درﻣﺎن ﺑﺎ داروﻫﺎی ﺷﻴﻤﻲدرﻣﺎﻧﻲ، مبتلایان به انواع بدخیمی، گیرندگان پیوند و مبتلایان به ایدز ﻧﺴﺒﺖ ﺑﻪ اﻓﺮاد ﻋـﺎدی، درﺻـﺪ ﺑﺎﻻﺗﺮی از آﻟﻮدﮔﻲﻫﺎی اﻧﮕﻠﻲ را ﻧﺸﺎن ﻣﻲدﻫﻨﺪ. بلاستوسیستیس هومینیس تک یاخته انگلی شایع در انسان است که انتشار جهانی داشته و به دفعات از نمونه های مدفوع در آزمایشگاه های انگل شناسی جدا میشود. ﻧﻘﺺ اﻳﻤﻨﻲ زﻣﻴﻨﻪ را ﺑﺮای اﺑـﺘﻼ ﺑـﻪ اﻧـﻮاع ﻋﻔﻮﻧـﺖﻫـﺎ ﻣـﺴﺎﻋﺪ ﻣﻲﻛﻨﺪ. ﻋﻔﻮﻧﺖ ﻫﺎی اﻧﮕﻠـﻲ ﺑـﻪ وﻳـﮋه اﻧﮕـﻞﻫـﺎی ﻓﺮﺻـﺖ ﻃﻠـﺐ، از ﻣﺸﻜﻼت اﺻﻠﻲ ﺑﻴﻤﺎران دﭼﺎر ﻧﻘﺺ سیستم اﻳﻤﻨﻲ اﺳﺖ.     علیرغم مطالعات متعددی که در نقاط مختلف جهان صورت گرفته است، اطلاعات جامع در خصوص اپیدمیولوژی آلودگی افراد دچار نقص سیستم ایمنی به بلاستوسیستیس هومسنیس در دسترس نیست. لذا این مطالعه مروری ساختاریافته به منظور جمع­آوری گزارشات حاصل از مطالعات انجام شده در نقاط مختلف دنیا و گردآوری اطلاعات به صورت یک مطالعه نظام­مند انجام می‌گیرد و امید است نتایج این مطالعه در راستای اقدامات پیشگیری و کنترل بیماری ایجاد شده با این انگل مفید واقع گردد.   B. hominis AIDS Metanalyses 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-465-en.docx

17-1108 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Hasan Valadbeigi hasan.valadbeigi@gmail.com Ebrahim Kouhsari ekouhsari1987@gmail.com Arezoo Khadiv arezoo.khadiv1366@gmail.com Hojat Sayadi sayyadi.h@gmail.com Nourkhoda Sadeghifard sadeghifard@gmail.com Helicobacter pylori heteroresistance clarithromycin heteroresistance metronidazole heteroresistance 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1108-en.docx

17-1245 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Gholam Basati gholam.basati@gmail.com Morteza Shams shamsimorteza55@gmail.com Hamidreza Majidiani hamidreza.majidiani@gmail.com Ali Asghari asghari3@yahoo.com Hassan Nourmohammadi hnm51@yahoo.com Serological investigation is the main method to achieve satisfactory results in Toxocara canis diagnosis. The accuracy of the native antigen used in the current diagnostic kits has proven to be insufficient as well as difficult to standardize. Therefore, significant efforts have been made to find alternative reagents as capture antigens. Multi-epitope peptides are potential diagnostic markers to improve the accuracy of diagnostic kits. The main aim of this study is the prediction and design of a novel synthetic protein consisting of multiple immunodominant B cell epitopes. Primary, secondary and tertiary structures of the proteins are analyzed by using several various online software (ExPasy, IEDB, ABCpred, SVMTriP). Then, B cell construct was assessed by machine learning and Physico-chemical approaches and finally, homology modeling of 3D structure of protein is evaluated. human Toxocara canis infection fine-tuned multi-epitope protein immunoinformatics 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1245-en.docx

17-1377 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Morteza Shams shamsimorteza55@gmail.com Gholam Basati gholam.basati@gmail.com Hamidreza Majidiani hamidreza.majidiani@gmail.com Hassan Nourmohammadi hnm51@yahoo.com Esfandyar Azizi azizi-e@medilam.ac.ir V leishmania major Proteine Vaccine 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1377-en.doc

17-1287 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Reza Pakzad rezapakzad2010@yahoo.com saber soltani sabersoltani71@gmail.com milad zandi miladzandi416@gmail.com sara akhavanrezayat saraakhavanrezayat@gmail.com zeinab Hosseini hosseinizeinab1987@gmail.com Pooneh Malekifar poonehmalekifar@gmail.com Iraj Pakzad pakzad_i2006@yahoo.com Habib kakaei habibkakaei67@gmail.com The ocular tropism of respiratory viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reported, and studies showed ocular manifestations in coronavirus disease 2019 (COVID-19) patient. The aims of the current systematic review and meta-analysis study will be to determine the prevalence of ophthalmic manifestation in COVID-19 patients. We will be searched the literature in Medline, Scopus, Web of Science, and Embase from December 1, 2019, until December 5, 2020, by using the main following MeSH keywords "SARS-CoV-2" and "ocular manifestations." The prevalence and 95% confidence interval (CI) will be calculated using binomial distribution and random effects. The meta-regression method will be utilized to investigate the factors affecting the heterogeneity. Ocular manifestation COVID-19 systematic review meta-analysis 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1287-en.docx

17-1438 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Ali Aidi aliaidi11@yahoo.com Elaheh Karimi elahehkarimi3913@gmail.com Mahmoud Bahmani mahmood.bahmani@gmail.com vahab hasan kaviar vahab.kaviar@gmail.com The increasing spread of drug and antibiotic resistance among bacteria has led to more attention being paid to finding pharmacological methods of resistance and also finding natural remedies suitable with fewer side effects. Laurentus plant is collected from Ilam city in Ilam province and after drying its leaves, essential oil and hydroalcoholic extract are prepared. The chemical composition of essential oil and leaf extract of Laurentus plant is measured by HS-SPME, GC-MS and HPLC-DAD methods. Medicinal plants are of particular interest due to their wide range of bioactive compounds as a potential source of new chemotherapy drugs, because herbal medicines are more compatible with living organisms, including the human body, due to their natural origin than chemical drugs. And cause fewer side effects. Therefore, by examining the antimicrobial effect of this plant, an effective step can be taken in its commercialization and use scientifically. And Pseudomonas aerosinosa. Chemical Analysis Laurentus GC-MASS 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1438-en.DOCX

17-1647 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Seyed Salman Zakariaee salman_zakariaee@yahoo.com Negar Naderi negarnaderi71@yahoo.com Danial Razaee Molood danial5719@gmail.com Prognostic accuracy of visual lung damage computed tomography score for mortality prediction in patients with COVID-19 pneumonia, a systematic review and meta-analysis Prognostic accuracy Covid-19 Computed tomography Mortality CT Pneumonia 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1647-en.docx

17-673 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Milad Azami milad98azami@gmail.com Mohammad Karimian drkarimian70@yahoo.com Majid Salamati salamati_majid@yahoo.com Fatemeh Kazemi F.kazemi810@gmail.com Amir Adibi amir771155@yahoo.com Reza Ranjbar ranjbarre@gmail.com Background: Dyspepsia is one of the most common gastrointestinal disorders. The aim of this study was to evaluate the prevalence of dyspepsia in Iran. Patients and methods: This study was registered in PROSPERO with code (CRD42019148610) and conducted based on Meta-analyses Of Observational Studies in Epidemiology) MOOSE) and reporting was done in accordance with the reporting was done in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). Systematic literature search was done in July 2019 using international online databases PubMed/Medline, Web of Science (ISI), Cochrane Library, Scopus, EMBASE, Science Direct, EBSCO, CINAHL, and national online databases Magiran, SID, RICST, IranDoc, Iranian National Library and Barakat Knowledge Network System and as well as Google Scholar. Heterogeneity was assessed using I2 and Chi-square tests. All analyses were performed with Comprehensive Meta-Analysis Software Prevalence dyspepsia Iran meta-analysis 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-673-en.docx

17-1926 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 ali saeidi alisaidiu@gmail.com Mohsen Jalilian jalilian91@yahoo.com behzad mahaki behzad.mahaki@gmail.com Effectiveness of educational program based on Transtheoretical model on physical activity stage of change in high school students of sharableh city   transtheoretical model physical activity adolescent health education 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1926-en.docx

17-1919 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Sobhan Ghafourian sobhan.ghafurian@gmail.com hamed khorami ha.khorami@gmail.com maysam aziznezhad Maysam.az@gmail.com somayeh mahdian S.mahdian1983@gmail.com PH measurement is one of the most common decomposition techniques used to determine the acid or base strength of a sample. This quantity can be done electronically using acid and base color reagents (in the form of paper or solution with color scale) and electronically. PH is measured electronically using an electrode. An electrode is an electrochemical sensor that includes a detector electrode and a reference electrode. The history of measuring the acidity of liquids electrically dates back to 1906, when Max Cremer, in his study of liquid interfaces (the interaction between liquids and solids), realized that the interface between liquids could be blown by blowing a bubble. Small glass and put one liquid inside it and another outside to be studied. In this way, an electrical voltage was generated that could be measured. The H-gauge measures the electrical potential between the mercury chloride at the reference electrode and its potassium chloride liquid, the unknown liquid, the solution inside the glass electrode, and the potential between this solution and the silver chloride. But only the potential between the unknown liquid and the solution inside the glass electrode changes from one sample to another. Therefore, the remaining voltages are measured without being present in the equation. The white mercury reference electrode consists of a glass tube with a potassium chloride (KCl) electrode in close contact with the mercury chloride element at the end of the KCl element. It is a brittle compound, which is in contact with a liquid connection tip made of porous ceramic or similar material. These types of electrodes are not easily contaminated with heavy metals and sodium. The glass electrode consists of a rigid glass tube to which a thin glass bubble is attached. Inside it is a known solution of potassium chloride (KCl) as a 7 + PH buffer. Establishes the interior. To reduce electronic interference, the probe is protected by a foil sheath, often found inside a glass electrode. Due to the time consuming nature of measuring the pH of materials with the current pH meter, we decided to use a device that can provide the appropriate pH in a hygienic environment, taking into account the minimum time and the intervention of human resources. . Therefore, the new device is able to do this and on the other hand, it creates this advantage so that we can localize the construction of this device and reduce costs by preventing transfers and currency. Liquid injection to achieve the required pH accurately and uniformly with a mixer at a gentle and uniform speed is one of the innovations of this design, which greatly reduces the risks of working with the solution by manpower. There are many examples of PH meters, but there is no example that creates a liquid with a selected pH and records events in diagrams, and if there is, it is limited and out of reach. pH meter acidic basic 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1919-en.docx

17-1901 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Sobhan Ghafourian sobhan.ghafurian@gmail.com mina Mahmoudi minaa.mahmoiudi68@gmail.com The ability of Pseudomonas aeruginosa to produce biofilm made it as a hard crisis to treat with current antibiotics. Some genes in bacteria like toxin antitoxin (TA) loci are responsible for regulating of the other genes like genes involved in biofilm production. So, by disrupting of these TA loci, they can be focused as novel anti-biofilm targets. Therefore, the current study aimed to evaluate different TA loci to find the reliable target for prevention of biofilm production. For this purpose, 30 P. aeruginosa clinical isolates were subjected to biofilm production and presence of different TA loci. For target discovery the target should be presence in biofilm producer isolates and should be functional means more express in strong biofilm producer bacteria; finally by knocked out of these TA loci the biofilm producer P. aeruginosa should become no biofilm producers. So, among 30 isolates relBE TA loci were presented in biofilm producers P. aeruginosa and if be presented in no biofilm isolates, it showed no expression. The functionality was confirmed by RT-qPCR, which the results demonstrated that the relBE TA loci expression was more in stronger biofilm producer isolates. Also, our findings showed by knocked out of relBE TA loci the isolate that be biofilm producer changed to no biofilm producer. The current study defined the role of relBE TA loci to regulate the biofilm production and showed relBE TA loci as a reliable anti-biofilm target in P. aeruginosa. Pseudomonas aeruginosa toxin antitoxin systems target discovery 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1901-en.docx

17-1866 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Sobhan Ghafourian sobhan.ghafurian@gmail.com Morovat Taheri Kalani taherikalani@gmail.com Iraj Pakzad pakzad_i2006@yahoo.com Nourkhoda Sadeghifard sadeghifard@gmail.com Background & objectives: Urinary tract infections (UTIs) caused by extended-spectrum beta lactamase (ESBL)-producing bacteria، Metallo-Beta-Lactamase (MBL)  have become a growing problem worldwide. The aim of this study was to Uropathogenic Bacterial and Antibiotic Resistance Pattern among patients Refereeing to Imam Khomaini Hospital, Ilam, Iran Methods:  In this cross - sectional study of patients with urinary tract infection in Imam Khomeini Hospital in Ilam were evaluated over a period of 9 months. All isolates were identified by routine biochemical methods and antimicrobial  susceptibility testing carried out by Kirby-Bauer method. Phenotypic confirmation test to detect ESBL, MBL, MRSA, VRSA and VRE antibiotic disk diffusion method was performed by disc. The results were interpreted according to the CLSI standard. Identification of genes SHV, CTX-M, TEM, VanA, mecA, bla VIM and bla IMP PCR was performed using the method. Results: 114 isolates were examined by 61.4% Escherichia-coli, 7% Citrobacter freundii, 7% Pseudomonas aeroginosa, 8% Enterobacterccloacae, 8% of Klebsiella poneumoniue, 4.1%Proteus mirabilis, 0.9% Acintobacter baumannii, 0.9% of Staphylococcus aureus, 0.9% Enterococcus faecalis and 1.8% diphtheroids were separated. Conclusion: Most isolates were resistant to the antibiotic cotrimoxazole (55%), cefotaxime (49%), ceftriaxone (41%) showed. 46 isolates (49.5%) ESBL were considered. Escherichia-coli 63%, 8% Citrobacter freundii , Pseudomonas aeroginosa  6%, 6%, Enterobacter cloacae, Proteus mirabilis 6%, 6% and 2% of Klebsiella pneumoniae were Acintobacter baumannii . In total, only 6.4% of the isolates were considered as phenotype MBL. The genotyping PCR method was shown that genes VIM1, VIM2 and IMP were not mentioned in any of the isolates. In between isolates of Gram-positive, none genotyped MRSA, VRSA and VRE was isolated. Only one (100%) Staphylococcus aureus isolates, for phenotypic VRSA was considered. The results of this study, as well as Gram-negative bacteria Enterobacteriaceae family, are the main factors that cause urinary tract infections.The results of this study show that the ESBLs produced in bacteria isolated from patients with urinary tract infection, which is up almost 49.5% of the isolates were ESBL and 6.4% MBL. Since, according to the study in Ilam high prevalence of ESBL-producing bacteria in the urinary tract infections and the prevalence is rising MBL. It is recommended that programs be seriously considered antibiotic use and prescribing of antibiotics is organized. As well as more studies are done on the MBL.   urinary tract infection(UTI) (ESBL) Extended-spectrum Beta-lactamasea (MRSA) Methicillin Resistance Staphylococcus Aureus disk diffusion method 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1866-en.docx

17-1862 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Sobhan Ghafourian sobhan.ghafurian@gmail.com mahsa jalili mahsajalili1993@gmail.com Iraj Pakzad pakzad_i2006@yahoo.com Abstract Unfortunately, today multidrug resistant (MDR) bacteria are very common in communities and could be a serious threat to human health. Consequently, bacterial populations contain new mechanism of survival strategy in hostile environments or antibiotic exposure. One of the most important mechanisms is persister cell formation in bacteria. Persister cell can be one of the important causes of chronic infections. Also, there are many challenges for combating persister cell. The discovery of new drugs and appropriate therapies in this area is very necessary. So, the purpose of the present research was discovery of an anti-persister drug against Pseudomonas aeruginosa clinical isolates. For this purpose, thirty P. aeruginosa clinical isolates were used for more analysis. Antibiotic susceptibility test and persister cell assay were performed. Finally, Peganum harmala was investigate as a likely source of an anti-persister cell drug. The finding demonstrated that concentration of 35ug/ml completely has the anti-persister properties. So, it can be herbal candidate against persister cells but further analysis including in vivo study and finding the main component should be done to commercial this herb as new anti-persister drug.   Persister cell Peganum harmala Pseudomonas aeroginosa 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1862-en.docx

17-1087 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Fakhredin taghinezhad taghynejad@yahoo.com Mohamadreza Kafashian m_r_kaffashian@yahoo.com Gholamreza Kalvandi pezeshk1351@yahoo.com Elham Shafiei eshafiei1524@gmail.com Since December 2019, coinciding with the outbreak of COIVD-19 in China and its spread to all countries, the greatest post-World War II health crisis and human society challenge has severely affected health systems, the global economy, and governments. [1] As previous priorities and routine activities in most areas have ceased and extensive efforts and investments have been made to prevent, diagnose and treat the disease, reduce the incidence rate, reduce the number of critically ill patients in need of intensive care and finally reduce the mortality rate [2]. Despite this unprecedented effort, various diagnostic and therapeutic aspects of the proposed and in use have been accompanied by many challenges and doubts so far [3]. Therefore, reducing the limitations and gaps in existing knowledge is the main priority and focus of studies in the field of medical sciences according to the encouragement of the World Health Organization. [4] According to studies, many factors can affect the prognosis of coronary heart disease and mortality. Most of the information on the epidemiological and laboratory factors of COVID-19 is insufficient and questionable, and there is insufficient evidence and evidence for its use. Recognizing the importance of each of the indicators related to mortality from disease, using efficient output models can in the process of treatment and better care, management of scarce resources during the peak of the disease, including prioritization of special beds and hospital beds, human resource management due to limitations Professional human resources, increasing the reliability of patients at lower risk for home care, appropriate planning for drug allocation and possible vaccines if used in the future. Therefore, the aim of this study was to explain the role of epidemiological and laboratory risk factors on the mortality of coronary patients using the artificial neural network model. Methods: The present study is a retrospective cohort study in which the demographic and laboratory characteristics of patients who referred from the onset of coronary heart disease (March 1) to July 1 with a definitive diagnosis of COVID-19 and improved or died were studied. they enter. Demographic, clinical and laboratory variables are then analyzed using the artificial network model to identify risk factors associated with patient mortality. After approving the plan and getting the code of ethics, information is collected from the files or the registry system. After completing the information through previous data, reviewing the files if necessary and contacting patients and their families, analysis and analysis using MATLAB software and effective factors in mortality, mediating variables, and the share of each The factor will be identified in explaining the variance of the dependent variable to determine the importance of each factor and ...... and the results will be presented in the form of analysis, table and graph. COVID_19 Artificial neural networks mortality 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1087-en.docx

17-1922 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Shahram Mohamadpour shahrammohammadpour@yahoo.com Naser Abbasi ilamfarma@gmail.com one of the most important causes of ischemia is stroke, which is the third leading cause of death in Western countries after myocardial infarction and cancer. Dies and 5 million people become permanently disabled. (2) Cerebral ischemia is a decrease in the amount of cerebral metabolites due to decreased blood flow, which leads to a decrease in oxygen storage and consequently the death of brain tissue or stroke. (3) Cerebral ischemia leads to movement, sensory and Vision, speech disorders, behavioral disorders, especially spatial learning disabilities. The effects of reperfusion are the result of the inflammatory function of the damaged tissue, which releases white blood cells, inflammatory factors such as interleukins, and free radicals into the damaged tissue as the blood returns, causing oxidative stress. (5) that certain areas of the brain and certain types of neurons, including pyramidal neurons in the CA1 region of the hippocampus and striatum, are more sensitive to cerebral ischemia. (6, 7) The hippocampus is the part of the brain that is located in the lateral ventricular floor of the temporal lobe and has specific areas called the dentate gyrus and the ammonia horn, which consists of three parts: CA1, CA2, CA3, and the neurons in each area. The hippocampus has unique biophysical properties, intracellular environment, and receptors (8). This has been implicated in the formation of new memory and the processing of spatial information (9), and it has been shown that differentiation of neuroblasts and production of new neurons in mammals begins in the two subgranular regions of the hippocampus and the ventricle of the olfactory bulb in the brain. 10, 11). The hippocampus is also supplied by the anterior choroidal artery, which is a branch of the internal carotid artery. , Epilepsy, stroke, ischemia and especially brain trauma. (12) Extensive research has been conducted to find an effective drug to reduce the damage caused by ischemia and restoration of blood flow (13), and much research has been done on stimulating neurogenesis through enriched environments, physical activity, and memory-related tasks. And learning, the use of therapeutic cells of different origins and antioxidants. Over the past 20 years, animal studies have shown beneficial effects of physical exercise on cerebral ischemia, including increased survival, reduced neurological defects, improvement in blood-brain barrier defects, and blood vessel integrity (14). Biochemical activity of the hippocampus following exercise strengthens memory (15) and it has been shown that physical activity has a neuroprotective effect against hippocampal damage that damages memory, as well as increasing the expression of neuronal growth factors such as insulin-like growth factor NGF and growth factors. Fibroblasts and vascular growth factor (16, 17) Other studies have shown that exercise reduces neuronal function as well as stroke volume in rats. (18) and reduces inflammatory damage by reducing the expression of inflammatory mediators as well as reducing leukocyte accumulation. [19] It also improves short-term memory and spatial memory by increasing neuron production as well as reducing apoptosis in the hippocampus. 20) According to many studies on reducing the damage to the hippocampus after ischemia-reperfusion induction, the effect of exercise neurogenesis on the hippocampus before ischemia has also been proven, but so far in the effect of swimming exercise on the hippocampus. After induction of ischemia-reperfusion, no comprehensive research has been done (therapeutic effect of exercise). Therefore, we investigate the effect of swimming exercise on mice hippocampus after ischemia-reperfusion induction Reperfusion ischemia hippocampus swimming exercise 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1922-en.docx

17-1888 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Asad Mirzaei amirzaeii@yahoo.com maryam alikhani mkh792@gmail.com Iraj Pakzad pakzad_i2006@yahoo.com 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1888-en.DOCX

17-1861 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Ardeshir Moayeri moayeri46@yahoo.com Naser Abbasi ilamfarma@gmail.com khoioud Ramz kh.ramz@yahoo.com Background and objective: In different societies, burns are one of factors wasting capital and time of countries around the word, recovery of which incurs huge expenditures and has a slow process as well as some side effects and disabilities which make such patients prone to be damaged mentally and psychologically. The aim of work was to evaluate the effects of Aloe vera and Vitis vinifera extract combination on wound healing second degree burn’s in male wistar rat and compared with SSD and other groups. Method:  72 male wistar rats were divided into 12 equal groups. The burn was made on the back of all rats, firstly dorsum of each rat was shaved and then the area was burned in order to 10 mm in diameter of second degree burn injury. The burned areas in the groups included: were not treated with any healing agent (control) and were treated topically with eucerin, treated with silver sulfadiazine ، covered with %5 ، %1 ، %1.5 ،%2 Vitis vinifera extract in eucerin base cream and, covered with %5 ، %1، %1.5 %2 Aloe vera extract in eucerin base cream and with aloe vera plus Vitis vinifera extract twice a day respectively. 21 days later the rats were sacrificed and burned skin tissue samples were collected from the rats for histopathological examination. They were evaluated parameters to be considered for review included the number of hair follicles, sebaceous glands of angiogenesis, inflammation, acute (severe infiltration of neutrophils) and the formation of an epithelial layer.   SSD - Aloe vera- Vitis vinifera- Second-degree burn 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-1861-en.docx

17-924 2026-10-17 10.1002

Technology and Research Information System doi 2022 5 1 Sanaz Mami sani_vet@yahoo.com Mohamadreza Kafashian m_r_kaffashian@yahoo.com Abdollah Davoodian abdolah.davodian@gmail.com Alireza Ahmadi alirezaahmadi6300@gmail.com Zahra Falahivastani z.falah@gmail.com IL-10.1L-18.IFN-G.COVID-19 2022 6 01 0 0 http://newresearch.medilam.ac.ir/article-1-924-en.docx