Journal title
عنوان نشریه
Technology and Research Information System
Literature & Humanities
http://newresearch.medilam.ac.ir
1
admin
doi
fa
jalali
1398
8
1
gregorian
2019
11
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2
3
online
1
fulltext
fa
شیوع سرمی توکسوپلاسما گوندی در زنان سنین باروری مراجعه کننده به آزمایشگاه های تشخیص طبی شهر ایلام در سال 1397
Seroprevalence of Toxoplasma gondii in women of child–bearing age referred to clinical laboratories in Ilam, western Iran
عمومي
General
مقطعی (Cross sectional)
Cross sectional
: <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">عفونت</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">اولیه</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">با</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">توکسوپلاسموز</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">در</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">طی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">حاملگی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">میتواند</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">به</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">جنین</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">منتقل</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">شود</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">و</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">عوارض</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">جدی ایجاد</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">نماید. با توجه به اهمیت توکسوپلاسموزیس، مطالعه ی حاضر با</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">هدف</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">تعیین</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">سروپریولنس</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">توکسوپلاسموز گوندی (</span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">T.gondii</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">)</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">در</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">زنان سنین باروری</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">مراجعه</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">کننده</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">به</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">آزمایشگاه های طبی شهر ایلام انجام شد.</span></span><br>
<strong><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">روش کار:</span></span></strong><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> این</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">مطالعه</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">از</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">نوع</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">توصیفی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">مقطعی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">است که در بازه ی زمانی فروردین 1394 تا فروردین 1396 انجام شد. نمونه گیری به صورت تصادفی انجام شد. تمامی زنان 15 تا 45 ساله مراجعه کننده آزمایشگاه های شهر ایلام مورد بررسی قرار گرفتند</span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">.</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> 5 سی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">سی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">خون</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">وریدی گرفته</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">شد و نمونه</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">ها به روش </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">ELISA</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> برررسی شدند. آنالیز آماری با استفاده از نرم افزار </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">SPSS</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> نسخه ی 17 انجام شد.</span></span><br>
<strong><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">نتایج: </span></span></strong><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">در طول مطالعه 797 زن در سن باروری با میانگین سنی 7.23</span></span><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">±</span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">29.92 سال بررسی شدند. </span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">سروپریولنس کلی </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">T.gondii</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> 23.5% (5/189 مورد) بود. سروپریولنس آنتی بادی های </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">IgG</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> و </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">IgM</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> ضد </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">T.gondii</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> به ترتیب 23.7% (189/797 مورد) و 0.6%(5/797 مورد) بود. ارتباط سروپریولنس آنتی بادی </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">IgG</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> ضد </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">T.gondii</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> و سن معنی دار بود (</span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">p<0.0001</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">) اما این ارتباط برای آنتی بادی </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">IgG</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> ضد </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">T.gondii</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> براساس آزمون من ویتنی معنی دار نبود (</span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">p=0.37</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">).</span></span><strong><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"></span></span></strong><br>
<strong><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">نتیجه گیری: </span></span></strong><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">نتایج مطالعه ی حاضر نشان دهد سروپریولنس </span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">آنتی بادی </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">IgG</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> ضد </span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">T.gondii</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> 23.7% می باشد که بسیار پایین است. لذا توصیه</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">می</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">شود تعیین</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">آنتیبادی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">ضد</span></span> <span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;">T.gondii</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"> در</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">زنان</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">در</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">هنگام مشاوره</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">ی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">ازدواج</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">و</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">بارداری</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">به</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">طور</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">معمول</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">جزء برنامه</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">های</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">آموزشی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">و</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">بهداشتی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">در</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">این</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">منطقه باشد</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">و</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">در</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">صورت</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">منفی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">بودن</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">آزمایش،</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">پیگیری</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">مجدد زنان</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">باردار</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">و</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">نیز</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">آموزش</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">و افزایش</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">آگاهی</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">ها</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">در</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">زمینه</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">راههای</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">انتقال</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">و</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">اهمیت</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">این</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">بیماری مورد توجه</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">قرار</span></span> <span style="font-family:B Nazanin;"><span style="font-size:16.0pt;">گیرد</span></span><span dir="LTR"><span style="font-family:Times New Roman,serif;"><span style="font-size:16.0pt;"> .</span></span></span><span style="font-family:B Nazanin;"><span style="font-size:16.0pt;"></span></span><br>
<strong>Background</strong>: Primary infection with toxoplasmosis during pregnancy can be transmitted to the fetus and may cause serious complications. Considering the importance of toxoplasmosis, the present study was conducted to determine the seroprevalence of toxoplasma gondii (<em>T.gondii</em>) toxoplasmosis in women of child-bearing age in Ilam<span dir="RTL">.</span><br>
<strong>Methods</strong>: This cross-sectional study was conducted during April 2015 and March 2017, on women of child-bearing age (15-49 years old) that referred to laboratories in Ilam. Sampling was done based on census. Five milliliter venous blood was collected from each participant and the samples were examined using ELISA method. Statistical analysis was performed using SPSS ver. 17. In the analytical statistics, Kruskal-Wallis and Mann-Whitney tests were used.<br>
<strong>Results</strong>: A total 797 women of child-bearing age with mean age of 29.92 ± 7.23 years were examined in this study. The total seroprevalence of <em>T. gondii </em>was 23.46% (187 cases). The seroprevalence of IgG and IgM antibodies against <em>T. gondii </em>was 23.4% and 0.6%, respectively. The relationship between seroprevalence of IgM antibody and age (P= 0.37), level of education (P= 0.501), occupation (P= 0.20), and residence (P= 0.761) were not significant. The relationship between seroprevalence of IgG antibody and level of education (P= 0.196), occupation (P= 0.711), and residence (P= 0.101) were not significant but it was significantly associated with age (P< 0.001).<br>
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<strong>Conclusion</strong>: The results of this study showed that the seroprevalence of IgG antibody against T. gondii is 23.7%, which is relatively high. Prenatal screening can help to identify susceptible women to <em>T. gondii</em>.
توکسوپلاسما گوندی, , باروری, آزمایشگاه های تشخیص طبی
Toxoplasma Gondii, Women, Reproductive, Antibodies
0
0
http://newresearch.medilam.ac.ir/browse.php?a_code=A-10-2456-17&slc_lang=fa&sid=1
Milad
Azami
میلاد
اعظمی
milad98azami@gmail.com
4490248474
100319475328460048872
Yes
Ilam University of Medical Sciences, Ilam, Iran
دانشگاه علوم پزشکی ایلام، ایلام، ایران