Journal title

fa مقایسه ارتباط بین تراکم ماست سلهاو ماکروفاژها و ریز عروق خونی در انواع اسکواموس سل کارسینومای دهان و پوست Association of mast cells and macrophage density with tumor angiogenesis in various type of oral and skin squamous cell carcinomas عمومي General مقطعی (Cross sectional) Cross sectional Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med 2001; 344:975-83. 2. Khiavi MM, Abdal K, Abbasi MM, et al. Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats. Indian J Med Res 2017; 145:112. 3. Manfredini M, Longo C, Ferrari B, et al. Dermoscopic and reflectance confocal microscopy features of cutaneous squamous cell carcinoma. J Eur Acad Dermatol Venereol 2017; 31:1828-33. 4. Zaidi MA, Mallick AK. A study on assessment of mast cells in oral squamous cell carcinoma. Ann Med Health Sci Res 2014; 4:457–60. 5. Carlile J, Harada K, Baillie R. Vascular endothelial growth factor (VEGF) expression in oral tissues: possible relevance to angiogenesis, tumour progression and field cancerisation. J Oral Pathol Med 2013; 30:449-57. 6. Macluskey M, Chandrachud LM, Pazouki S. Apoptosis, proliferation, and angiogenesis in oral tissues. Possible relevance to tumour progression. J Pathol 2010; 191:368-75. 7. Gudiseva S, Santosh AB, Chitturi R, et al. The role of mast cells in oral squamous cell carcinoma. Contemp Oncol 2017; 21:21. 8. Cheema VS, Ramesh V, Balamurali PD. The relevance of mast cells in oral squamous cell carcinoma. J Clin Diagn Res 2012; 6:1803-07. 9. Conti P, Castellani ML, Kempuraj D, et al. Role of mast cell in tumor growth. Ann Clin Lab Sci 2007; 37:315-22. 10. Shivamallappa SM, Venkatraman NT, Shreedhar B, et al. Role of angiogenesis in oral squamous cell carcinoma development and metastasis: An immunohistochemical study. Int J Oral Sci 2011; 3:216-24. 11. Wadhwan V, Sharma P, Saxena C, et al. Grading angiogenesis in oral squamous cell carcinoma: A histomorphometric study. Indian J Dent Res 2015; 26:26-30. 12. Florence ME, Massuda JY, Bröcker EB, et al. Angiogenesis in the progression of cutaneous squamous cell carcinoma: An immunohistochemical study of endothelial markers. Clinics (Sao Paulo) 2011; 66:465-68. 13. Dodani A, Siadati S, Salehinejad J, et al. Comparative evaluation of the frequency ofAlam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med 2001; 344:975-83. 2. Khiavi MM, Abdal K, Abbasi MM, et al. Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats. Indian J Med Res 2017; 145:112. 3. Manfredini M, Longo C, Ferrari B, et al. Dermoscopic and reflectance confocal microscopy features of cutaneous squamous cell carcinoma. J Eur Acad Dermatol Venereol 2017; 31:1828-33. 4. Zaidi MA, Mallick AK. A study on assessment of mast cells in oral squamous cell carcinoma. Ann Med Health Sci Res 2014; 4:457–60. 5. Carlile J, Harada K, Baillie R. Vascular endothelial growth factor (VEGF) expression in oral tissues: possible relevance to angiogenesis, tumour progression and field cancerisation. J Oral Pathol Med 2013; 30:449-57. 6. Macluskey M, Chandrachud LM, Pazouki S. Apoptosis, proliferation, and angiogenesis in oral tissues. Possible relevance to tumour progression. J Pathol 2010; 191:368-75. 7. Gudiseva S, Santosh AB, Chitturi R, et al. The role of mast cells in oral squamous cell carcinoma. Contemp Oncol 2017; 21:21. 8. Cheema VS, Ramesh V, Balamurali PD. The relevance of mast cells in oral squamous cell carcinoma. J Clin Diagn Res 2012; 6:1803-07. 9. Conti P, Castellani ML, Kempuraj D, et al. Role of mast cell in tumor growth. Ann Clin Lab Sci 2007; 37:315-22. 10. Shivamallappa SM, Venkatraman NT, Shreedhar B, et al. Role of angiogenesis in oral squamous cell carcinoma development and metastasis: An immunohistochemical study. Int J Oral Sci 2011; 3:216-24. 11. Wadhwan V, Sharma P, Saxena C, et al. Grading angiogenesis in oral squamous cell carcinoma: A histomorphometric study. Indian J Dent Res 2015; 26:26-30. 12. Florence ME, Massuda JY, Bröcker EB, et al. Angiogenesis in the progression of cutaneous squamous cell carcinoma: An immunohistochemical study of endothelial markers. Clinics (Sao Paulo) 2011; 66:465-68. 13. Dodani A, Siadati S, Salehinejad J, et al. Comparative evaluation of the frequency ofAlam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med 2001; 344:975-83. 2. Khiavi MM, Abdal K, Abbasi MM, et al. Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats. Indian J Med Res 2017; 145:112. 3. Manfredini M, Longo C, Ferrari B, et al. Dermoscopic and reflectance confocal microscopy features of cutaneous squamous cell carcinoma. J Eur Acad Dermatol Venereol 2017; 31:1828-33. 4. Zaidi MA, Mallick AK. A study on assessment of mast cells in oral squamous cell carcinoma. Ann Med Health Sci Res 2014; 4:457–60. 5. Carlile J, Harada K, Baillie R. Vascular endothelial growth factor (VEGF) expression in oral tissues: possible relevance to angiogenesis, tumour progression and field cancerisation. J Oral Pathol Med 2013; 30:449-57. 6. Macluskey M, Chandrachud LM, Pazouki S. Apoptosis, proliferation, and angiogenesis in oral tissues. Possible relevance to tumour progression. J Pathol 2010; 191:368-75. 7. Gudiseva S, Santosh AB, Chitturi R, et al. The role of mast cells in oral squamous cell carcinoma. Contemp Oncol 2017; 21:21. 8. Cheema VS, Ramesh V, Balamurali PD. The relevance of mast cells in oral squamous cell carcinoma. J Clin Diagn Res 2012; 6:1803-07. 9. Conti P, Castellani ML, Kempuraj D, et al. Role of mast cell in tumor growth. Ann Clin Lab Sci 2007; 37:315-22. 10. Shivamallappa SM, Venkatraman NT, Shreedhar B, et al. Role of angiogenesis in oral squamous cell carcinoma development and metastasis: An immunohistochemical study. Int J Oral Sci 2011; 3:216-24. 11. Wadhwan V, Sharma P, Saxena C, et al. Grading angiogenesis in oral squamous cell carcinoma: A histomorphometric study. Indian J Dent Res 2015; 26:26-30. 12. Florence ME, Massuda JY, Bröcker EB, et al. Angiogenesis in the progression of cutaneous squamous cell carcinoma: An immunohistochemical study of endothelial markers. Clinics (Sao Paulo) 2011; 66:465-68. 13. Dodani A, Siadati S, Salehinejad J, et al. Comparative evaluation of the frequency ofAlam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med 2001; 344:975-83. 2. Khiavi MM, Abdal K, Abbasi MM, et al. Comparison of injectable doxorubicin & its nanodrug complex chemotherapy for the treatment of 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma in rats. Indian J Med Res 2017; 145:112. 3. Manfredini M, Longo C, Ferrari B, et al. Dermoscopic and reflectance confocal microscopy features of cutaneous squamous cell carcinoma. J Eur Acad Dermatol Venereol 2017; 31:1828-33. 4. Zaidi MA, Mallick AK. A study on assessment of mast cells in oral squamous cell carcinoma. Ann Med Health Sci Res 2014; 4:457–60. 5. Carlile J, Harada K, Baillie R. Vascular endothelial growth factor (VEGF) expression in oral tissues: possible relevance to angiogenesis, tumour progression and field cancerisation. J Oral Pathol Med 2013; 30:449-57. 6. Macluskey M, Chandrachud LM, Pazouki S. Apoptosis, proliferation, and angiogenesis in oral tissues. Possible relevance to tumour progression. J Pathol 2010; 191:368-75. 7. Gudiseva S, Santosh AB, Chitturi R, et al. The role of mast cells in oral squamous cell carcinoma. Contemp Oncol 2017; 21:21. 8. Cheema VS, Ramesh V, Balamurali PD. The relevance of mast cells in oral squamous cell carcinoma. J Clin Diagn Res 2012; 6:1803-07. 9. Conti P, Castellani ML, Kempuraj D, et al. Role of mast cell in tumor growth. Ann Clin Lab Sci 2007; 37:315-22. 10. Shivamallappa SM, Venkatraman NT, Shreedhar B, et al. Role of angiogenesis in oral squamous cell carcinoma development and metastasis: An immunohistochemical study. Int J Oral Sci 2011; 3:216-24. 11. Wadhwan V, Sharma P, Saxena C, et al. Grading angiogenesis in oral squamous cell carcinoma: A histomorphometric study. Indian J Dent Res 2015; 26:26-30. 12. Florence ME, Massuda JY, Bröcker EB, et al. Angiogenesis in the progression of cutaneous squamous cell carcinoma: An immunohistochemical study of endothelial markers. Clinics (Sao Paulo) 2011; 66:465-68. 13. Dodani A, Siadati S, Salehinejad J, et al. Comparative evaluation of the frequency of Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05) between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore, according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting the progression, malignant potential and invasion of OSCC compared to CSCC. Key words: Squamous cell carcinoma, Mast cell, Microvessel, Prognosis 0 0 http://newresearch.medilam.ac.ir/browse.php?a_code=A-10-2346-6&slc_lang=fa&sid=1 Khadijeh Abdal mahmoodabadi خدیجه ابدال محمودآبادی dr.faribaabdal@yahoo.com 0381820424 100319475328460071445 Yes Department of Oral and Maxillofacial Pathology, School of Dentistry, Ilam University of Medical sciences, Ilam, Iran گروه آموزشی پاتولوژی دندان، دانشکده دندانپزشکی، دانشگاه علوم پزشکی ایلام، ایلام، ایران