fa تعیین شیوع اختلال های انعقادی در بین جمعیت ایرانی: یک مطالعه مرور سیستماتیک و متانالیز هماتولوژی و انکولوژی مرور سیستماتیک و متاآنالیزیس <span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span arial="" style="font-family:"><span b="" nazanin="" style="font-family:">هموستاز فرایندی است که نقش مهمی در جلوگیری از خونریزی دارد. این سیستم شامل هموستاز اولیه و ثانویه است. سیستم انعقاد و فیبرینولیز از بخش های هموستاز ثانویه می باشند. &nbsp;کمبود یا فقدان فاکتورهای سیستم انعقادی و فیبرینولیز&nbsp; منجر به اختلالات خونریزی دهنده</span>&nbsp; <span b="" nazanin="" style="font-family:">و یا ترمبوز&nbsp; می شود(1)</span><span dir="LTR" style="font-family:"Times New Roman","serif""></span></span></span></span></span><br> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">اختلالات</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">خونریزی</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">و</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ترومبوز</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">دارای اهمیت می باشند،</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">زیرا</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">می</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">توانند</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">زندگی</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">را</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تهدید</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">کنند. از جمله موارد تهدید کننده حیات، نقص های فاکتور8 ، 9 و 5 لیدن می باشد.</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">بیماران</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">هموفیلی(نقص فاکتور 8 و 9)</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ممکن</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">است</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">حین</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">جراحی</span></span>&nbsp; <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">یا</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تروما</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">به</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">دلیل</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">خونریزی</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">جان</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">خود</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">را</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">از</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">دست</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">بدهند(2).</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">همچنین</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">بیماران</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">دارای</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">فاکتور</span></span><span style="font-size:12.0pt"><span arial="" style="font-family:"> V </span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">لیدن</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مستعد</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ترومبوز</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">هستند</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">.</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">این</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">بیماران،</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">لخته</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">شدن</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مغز</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">می</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تواند</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">منجر</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">به</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">سکته</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">شود(3). تا</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">&nbsp;اکنون،</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">جنبه</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">های</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مختلف</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">اختلالات</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">انعقادی</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">خون</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">بررسی</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">شده</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">است</span></span><span style="font-size:12.0pt"><span arial="" style="font-family:">.</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تأثیر</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">پلی</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">‌</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مورفیسم</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">‌</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ها</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">و</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">جهش</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">‌</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ها</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">کاهش</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">یا</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">افزایش</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">فعالیت</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">فاکتورهای</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">انعقادی</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">و</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">پیامدهای</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">آن</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">از</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">جمله</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ترومبوز</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">و</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">خونریزی و</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تاثیر ازدواج های فامیلی ، جنسیت و نژاد در شیوع این اختلالات</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> از</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">این</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">موارد</span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">است(4).</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> با توجه به پراکندگی مطالعه های اختلال های انعقادی در ایران، وجود یک مطالعه مروری به صورت سیستماتیک لازم می باشد</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">. در نتیجه، هدف از این مطالعه تعیین شیوع اختلال های انعقادی در بین جمعیت ایرانی می باشد</span></span> <span style="font-size:14pt"><span style="line-height:115%"><span style="font-family:"><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Hemostasis is a process that plays an important role in preventing bleeding. This system includes primary and secondary homeostasis. Coagulation system and fibrinolysis are parts of secondary homeostasis. Deficiency or lack of coagulation system factors and fibrinolysis leads to bleeding disorders or thrombosis (1).</span></span></span></span></span></span><br> <span style="font-size:14pt"><span style="line-height:115%"><span style="font-family:"><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Bleeding disorders and thrombosis are important, because they can be life-threatening. Factor VIII, XI and V Leiden defects are among the life-threatening cases. Patients with hemophilia (factor VIII and IX deficiency) may die during surgery or trauma due to bleeding (2). Also, patients with factor V Leiden are prone to thrombosis. In these patients, clotting in the brain can lead to a stroke (3). Until now, various aspects of blood coagulation disorders have been investigated. The effect of polymorphisms and mutations include reducing or increasing the activity of coagulation factors and its outcomes, including thrombosis and bleeding. Also, the effect of consanguineous marriages, gender and race in the prevalence of these disorders are impotence (4). Considering the dispersion of studies on coagulation disorders in Iran, a systematic review is necessary. As a result, the aim of this study is to determine the prevalence of coagulation disorders among the Iranian population</span></span></span></span></span></span><br> &nbsp; هموستاز,اختلال های انعقادی, جمعیت ایرانی Hemostasis,mutation,iranian papulation 0 0 http://newresearch.medilam.ac.ir/browse.php?a_code=A-10-3228-2&slc_lang=fa&sid=1 sadegh abbasian صادق عباسیان abbasian_sadegh@yahoo.com 4529906604 100319475328460064057 Yes ilam علوم پزشکی ایلام hassan boostani حسن بوستانی hassanboostani@ymail.com 4549901381 100319475328460064058 No ilam علوم پزشکی ایلام fatemeh mezginejad فاطمه مزگی نژاد f.mejginejad@yahoo.com 4549901381 100319475328460064059 No birjand علوم پزشکی بیرجند mahnosh abbassadeh مهنوش عباس زاده mahnosh.d@yahoo.com 4549901381 100319475328460064060 No iran ایران negin shokrgozar نگین شکرگزار shokrgozar.n@yahoo.com 0454361580 100319475328460064061 No shiraz علوم پزشکی شیراز