fa : بررسی تعیین اثر ترکیب عصاره برگ‌های Aloe vera و vinifera Vitis برروی بهبود سوختگی درجه دوم در موش‌های رت نژاد ویستار سایر.... آزمایشگاهی <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:"><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">نظر به اهمیت سوختگی در جوامع انسانی وبا توجه به این&shy;که خسارت&shy;های جانی واقتصادی فراوانی بر جوامع انسانی ازجهت مداوا وترمیم ضایعات تحمیل می&shy;کندامروزه توجه به داروهای گیاهی می&shy;تواند درکاهش اثارمنفی داروهای صناعی موثر باشد .</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:"><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">هدف : هدف از این مطالعه ارزیابی اثرات ترکیب عصاره برگ&shy;های</span></span></span><i><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Aloe vera</span></span></span></i> <span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&nbsp;و </span></span></span>&nbsp;<i><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Vitis vinifera</span></span></span></i><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> برروی بهبود زخم سوختگی درجه دوم می&shy;باشد این سوختگی در موش&shy;های نر نژاد ویستار انجام میشود وبا اثرات درمانی در گروه&shy;های مداوا شده با </span></span></span><i><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">SSD</span></span></span></i> <span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%">, </span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&nbsp;کنترل </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%">,</span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> شم &nbsp;مقایسه خواهد شد .</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:"><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">مواد وروش</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%">&shy;</span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">ها :</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:"><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">72&nbsp; سر موش نر نژاد ویستار در 12 گروه 6تایی وبه &shy;طور برابر انتخاب شدند سوختگی پس از تراشیدن پشت انها با یک ابزار تیز (</span></span></span><i><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">shave</span></span></span></i><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">)ایجاد گردید وسپس منطقه بدون مو بایک وسیله به قطر 10</span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%">mm</span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> سوختگی درجه دوم ایجاد خواهد شد.</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="line-height:115%"><span calibri="" style="font-family:"><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">منطقه سوختگی در گروه 1 به وسیله هیچ ماده ای مداوا نخواهد شد&nbsp; (کنترل ) ، در گروه 2 مداوا تنها به وسیله اوسرین (کرم پایه ) صورت&nbsp; خواهدگرفت </span></span></span>&nbsp;&nbsp;<span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">در گروه سوم به وسیله(سیلورسولفادیازین </span></span></span><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%">&nbsp;( </span></span><i><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">SSD</span></span></span></i><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">مداوا انجام&nbsp; خواهد شد در گروه&shy;های 4تا7 به وسیله غلظت&shy;های 5% ، 1% ،&nbsp; 1.5% و 2% از آلوئه ورا در کرم پایه اوسرین وگروه 11-8 به وسیله غلظت&shy;های 5% ، 1% ،&nbsp; 1.5% و 2% از </span></span></span><i><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Vitis vinifea </span></span></span></i><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&nbsp;در کرم پایه اوسرین&nbsp; و گروه 12 بصورت ترکیب دو عصاره برگ&shy;های </span></span></span><i><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Aloe vera</span></span></span></i><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> و </span></span></span><i><span dir="LTR" style="font-size:14.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Vitis vinifea</span></span></span></i> <span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&nbsp;(5/1&nbsp; :&nbsp; 5/1&nbsp; ) مورد استفاده قرار خواهد گرفت ومداوا توسط این پمادها 2 بار در روز و به مدت 21 روز صورت خواهد گرفت بعداز 21 روز نمونه بردار از بافت&shy;ها انجام خواهد شد وتوسط پاتولوژِیست وبه صورت یک سویه کور بررسی خواهد شد .</span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><i><u><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:red">Background and objective</span></span></span></span></u></i></b><i><u><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:red">: </span></span></span></span></u></i></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><i><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">In different societies, burns are one of factors wasting capital and time of countries around the word, recovery of which incurs huge expenditures and has a slow process as well as some side effects and disabilities which make such patients prone to be damaged mentally and psychologically.</span></span></span></i></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><i><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">The aim of work was to evaluate the effects of Aloe vera and Vitis vinifera extract combination on wound healing second degree burn&rsquo;s in male wistar rat and compared with SSD and other groups.</span></span></span></i></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><i><u><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:red">Method</span></span></span></span></u></i></b><b><i><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">:</span></span></span></i></b></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><i><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">&nbsp;72 male wistar rats were divided into 12 equal groups. The burn was made on the back of all rats, firstly dorsum of each rat was shaved and then the area was burned in order to 10 mm in diameter of second degree burn injury. </span></span></span></i></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><i><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">The burned areas in the groups included: were not treated with any healing agent (control) and were treated topically with eucerin, treated with silver sulfadiazine </span></span></span></i><i><span dir="RTL" lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">،</span></span></span></i><i> </i><i><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">covered with <span style="color:#00b050">%5</span></span></span></span></i><i><span dir="RTL" lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> ،</span></span></span></i><i> </i><i><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">%1 ، %1.5 ،%2 Vitis vinifera extract in eucerin base cream and, covered </span></span></span></i><i><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">with <span style="color:#00b050">%5</span></span></span></span></i><i><span dir="RTL" lang="FA" style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> ،</span></span></span></i><i> </i><i><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">%1، %1.5 %2 Aloe vera extract in eucerin base cream and with <span style="color:#00b050">aloe vera plus</span> Vitis vinifera extract twice a day respectively. 21 days later the rats were sacrificed and burned skin tissue samples were collected from the rats for histopathological <span style="color:#00b050">examinatio</span>n. </span></span></span></i><i><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:black">They were evaluated parameters to be considered for review included the number of hair follicles, sebaceous glands of angiogenesis, inflammation, acute (severe infiltration of neutrophils) and the formation of an epithelial layer.</span></span></span></span></i></span></span></span><br> &nbsp; سوختگی درجه دوم , پماد نقره, آلوئه ورا, برگ مو SSD - Aloe vera- Vitis vinifera- Second-degree burn 0 0 http://newresearch.medilam.ac.ir/browse.php?a_code=A-10-2379-14&slc_lang=fa&sid=1 Ardeshir Moayeri اردشیر معیری moayeri46@yahoo.com 2709278200 100319475328460068455 Yes Department of Anatomical Sciences, School of Medicine, Ilam University of Medical sciences, Ilam, Iran گروه آموزشی آناتومی و تشریح، دانشکده پزشکی، دانشگاه علوم پزشکی ایلام، ایلام، ایران Naser Abbasi ناصر عباسی ilamfarma@gmail.com 4559758026 100319475328460068456 No Biotechnology and Medicinal Plants Research Center, Ilam University of Medical sciences, Ilam, Iran مرکز تحقیقات زیست فناوری و گیاهان دارویی، دانشگاه علوم پزشکی ایلام، ایلام، ایران khoioud Ramz خلود رمز kh.ramz@yahoo.com 2709278200 100319475328460068457 No medical Sciences of ilam university دانشگاه علوم پزشکی ایلام