fa مطالعه مروری سیستماتیک و متاآنالیز اثر مصرف محلول فروکتوز با غلظت بالا، بر القاء مقاومت به انسولین در موش صحرایی بعنوان مدل حیوانی دیابت نوع دو عمومي General مقطعی (Cross sectional) Cross sectional هدف از مطالعه حاضر، بررسی ارتباط بین میزان تأثیر مصرف فروکتوز و خطر نسبی از HP بر اساس پارامترهای مختلفی از جمله؛ روش تغذیه فروکتوز، مدت زمان درمان فروکتوز و نژاد حیوانات بود High fructose feeding has been suggested to involve in several features of metabolic syndrome including hyperuricemia (HP). We designed and implemented a study to determine the effect size of fructose intake and the relative risk of HP based on the type of fructose feeding (diet or solution), duration of treatment (2&ndash;6, 7&ndash;10, and > 10 weeks), and animal race. The required information was accepted from international databases, including PubMed/MEDLINE, Science Direct, Scopus, and etc., from 2009 until 2019 on the basis of predetermined eligibility criteria. The data selection and extraction and quality assessment were performed independently by two researchers. Results were pooled as random effects weighting and reported as standardized mean differences with 95% confidence intervals. Thirty-five studies including 244 rats with fructose consumption were included in the final analysis. The heterogeneity rate of parameters was high (I2 = 81.3%, p < 0.001) and estimated based on; 1) type of fructose feeding (diet; I2 = 79.3%, solution 10%; I2 = 83.4%, solution 20%; I2 = 81.3%), 2) duration of treatment (2&ndash;6 weeks; I2 = 86.8%, 7&ndash;10 weeks; I2 = 76.3%, and > 10 weeks; I2 = 82.8%), 3) the animal race (Wistar; I2 = 78.6%, Sprague-Dawley; I2 = 83.9%). Overall, the pooled estimate for the all parameters was significant (p < 0.001). The results of this study indicated that a significant relationship between HP and fructose intake regardless of the treatment duration, animal race, fructose concentration and route of consumption. انسولین ,فروکتوز Fructose, Rats, Uric acid, Hyperuricemia, Meta-analysis, Systematic review 0 0 http://newresearch.medilam.ac.ir/browse.php?a_code=A-10-2437-7&slc_lang=fa&sid=1 Enayat Anvari عنایت انوری anvari_ph@yahoo.com 4500783318 100319475328460011111 Yes Department of Physiology, School of Medicine, Ilam University of Medical sciences, Ilam, Iran گروه آموزشی فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی ایلام، ایلام، ایران Kourosh Sayehmiri کورش سایه میری sayehmiri-k@medilam.ac.ir 4500980369 100319475328460011112 No Psychosocial Injuries Research Center, Ilam University of Medical sciences, Ilam, Iran مرکز تحقیقات آسیب‌های روانی و اجتماعی، دانشگاه علوم پزشکی ایلام، ایلام، ایران