Journal title
عنوان نشریه
Technology and Research Information System
Literature & Humanities
http://newresearch.medilam.ac.ir
1
admin
doi
fa
jalali
1399
2
1
gregorian
2020
5
1
3
1
online
1
fulltext
fa
مطالعه مروری سیستماتیک و متاآنالیز اثر مصرف محلول فروکتوز با غلظت بالا، بر القاء مقاومت به انسولین در موش صحرایی بعنوان مدل حیوانی دیابت نوع دو
Metanalysis and systematic review of high fructose solution intake on insulin resistance induction in rats as animal model of type two diabetes
عمومي
General
مقطعی (Cross sectional)
Cross sectional
هدف از مطالعه حاضر، بررسی ارتباط بین میزان تأثیر مصرف فروکتوز و خطر نسبی از HP بر اساس پارامترهای مختلفی از جمله؛ روش تغذیه فروکتوز، مدت زمان درمان فروکتوز و نژاد حیوانات بود
High fructose feeding has been suggested to involve in several features of metabolic syndrome including hyperuricemia (HP). We designed and implemented a study to determine the effect size of fructose intake and the relative risk of HP based on the type of fructose feeding (diet or solution), duration of treatment (2–6, 7–10, and > 10 weeks), and animal race. The required information was accepted from international databases, including PubMed/MEDLINE, Science Direct, Scopus, and etc., from 2009 until 2019 on the basis of predetermined eligibility criteria. The data selection and extraction and quality assessment were performed independently by two researchers. Results were pooled as random effects weighting and reported as standardized mean differences with 95% confidence intervals. Thirty-five studies including 244 rats with fructose consumption were included in the final analysis. The heterogeneity rate of parameters was high (I2 = 81.3%, p < 0.001) and estimated based on; 1) type of fructose feeding (diet; I2 = 79.3%, solution 10%; I2 = 83.4%, solution 20%; I2 = 81.3%), 2) duration of treatment (2–6 weeks; I2 = 86.8%, 7–10 weeks; I2 = 76.3%, and > 10 weeks; I2 = 82.8%), 3) the animal race (Wistar; I2 = 78.6%, Sprague-Dawley; I2 = 83.9%). Overall, the pooled estimate for the all parameters was significant (p < 0.001). The results of this study indicated that a significant relationship between HP and fructose intake regardless of the treatment duration, animal race, fructose concentration and route of consumption.
انسولین ,فروکتوز
Fructose, Rats, Uric acid, Hyperuricemia, Meta-analysis, Systematic review
0
0
http://newresearch.medilam.ac.ir/browse.php?a_code=A-10-2437-7&slc_lang=fa&sid=1
Enayat
Anvari
عنایت
انوری
anvari_ph@yahoo.com
4500783318
100319475328460011111
Yes
Department of Physiology, School of Medicine, Ilam University of Medical sciences, Ilam, Iran
گروه آموزشی فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی ایلام، ایلام، ایران
Kourosh
Sayehmiri
کورش
سایه میری
sayehmiri@razi.tums.ac.ir
4500980369
100319475328460011112
No
Psychosocial Injuries Research Center, Ilam University of Medical sciences, Ilam, Iran
مرکز تحقیقات آسیبهای روانی و اجتماعی، دانشگاه علوم پزشکی ایلام، ایلام، ایران