Showing 2 results for Giardia Lamblia
Pi Soghra Vaisi, Copi Jahangir Abdi,
Volume 1, Issue 4 (3-2019)
Abstract
Background:
Giardiasis is one of the most important problems health in different countries of the world which causes long-term digestive disorders and risk factors are among the factors that affect this parasite. Therefore, the aim of this study was to investigate the relationship between Giardia lamblia and Gastrointestinal Disorders. Then investigate risk factors In Ilam city and also provide strategies for patient treatment and finally providing strategies for treating patients and identifying risk factors to reduce giardiasis.
Materials and methods:
This descriptive cross-sectional study was conducted on random sampling of stool from 1000 people referred to Ilam labs in 2017. All specimens were examined using direct and ethanol formaldehyde. Suspect specimens were examined using Trachoma staining. Demographic information was also recorded in a questionnaire, and finally the results were analyzed using statistical software SPSS 20.The data were then compared with Chi-square test, and finally investigated the relationship between parasites with digestive disorders and risk factors.
Results:
Of the 1,000 patients studied, 84 (8.4%) were infected with Giardia parasite. The frequency of giardiasis was more in the age group of 20-30 years and in men more than in women. Clinical symptoms among the different age groups were 3/1% Stomach ache, 2.8% bloating, 1.6% diarrhea and 0.8% weight loss, respectively.
Conclusion
Despite the improvement of public health, Giardiasis is still considered as a health problem and causes gastrointestinal disorders in the city of Ilam. Therefore, proper planning, public health education, and the provision of safe drinking water are among the strategies for reducing Giardia infection in the region.
Jahangir Abdi, Student Aram Mohamadyan,
Volume 4, Issue 1 (5-2021)
Abstract
Giardia lamblia (G. lamblia) is one of the most common intestinal parasites worldwide. There are some side effects and the reports of parasite resistance to metronidazole as the first line treatment of giardiasis. Therefore, it is essential to discover an effect and safe drug to treat giardiasis. Methodology: In this study, the anti-parasitic activity of hydroalcoholic extracts of Capparis spinosa Linn (C. spinosa) leaves and fruits with different concentrations (4 to 0.125 mg/ml) was assessed against human isolates of the G. lamblia cysts and incubated at 37℃. After staining Giardia cysts with 0.1% eosin, the lethal percentage and 50% lethal concentration (LC50) of fruit Original Research Article Mohamadian et al.; JPRI, 33(29A): 224-230, 2021; Article no.JPRI.68272 225 and leave C. spinosa L extracts and metronidazole on G. lamblia cysts were calculated after 3, 6, 24 and 48 hours. Results: Anti-giardia activity of fruit and leaf extracts of C. spinosa was different between concentrations and time points (p<0.005). The lethal effect of both C. spinosa L extracts and metronidazole increased significantly in a concentration - and time–dependent response (P<0.0001). The highest lethal percentage of G. lamblia cysts was observed a concentration of 4 mg / ml of fruit (100%) and leaf (44%) extracts of C. spinosa L after 48 hours, respectively. LC50 values were 0.38 ± 0.02mg/ml for fruit extract, 2.32 ± 0.1 mg/ml for leaf extract and 0.53 ± 0.03 µg/ml for metronidazole after 48hours. Conclusion: C. spinosa can be effective in eliminating Giardia cyst of contaminated environments and wa
