Volume 3, Issue 3 (11-2020)
2020, 3(3): 0-0 |
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Ethics code: IR.MEDILAM.REC.1399.051
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Noorimotlagh Z, Mami S, Kafashian M, Mirzaee S A, karami C. Immuno and bio informatics identification of T cell and B cell epitopes in the protein structure of SARS coronavirus 2. Journal title 2020; 3 (3)
URL: http://newresearch.medilam.ac.ir/article-1-928-en.html
URL: http://newresearch.medilam.ac.ir/article-1-928-en.html
Psychosocial Injuries Research Center, Ilam University of Medical sciences, Ilam, Iran
Abstract: (2877 Views)
The beginning of 2020 has seen the development of a COVID-19 outbreak caused by a new coronavirus, The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is no vaccine or approved treatment for this emerging infection so the presentation of a proper vaccine is required. Several techniques facilitating the combination of the immunoinformatics approach and comparative genomic approach were used to determine the potential peptides for designing the T-cell epitope-based peptide vaccine using the envelope protein of 2019-nCoV as a target in some of the studies. By screening the bioimmunoinformatic SARS-CoV2 derived B-cell and T-cell epitopes within the basic immunogenic of SARS-CoV2 proteins, we presented a set of inferred B-cell and T-cell epitopes from the spike (S) and nucleocapsid (N) proteins that are high antigenicity and without allergenic property or toxic effects. Our discoveries provide a screened set of epitopes that can be introduced as potential targets for developing peptide vaccines against the SARS-CoV-2 virus.
Received: 2020/04/15 | Accepted: 2020/04/27 | Published: 2020/11/30
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