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Rahmani A, Khalighi Z, Hafezi Ahmadi M. Effect of perflourocarbon on inflammatory markers, lipid proxidation and pathologic Characteristic in rat lung fibrosis induced by paraquat. Journal title 2019; 2 (3)
URL: http://newresearch.medilam.ac.ir/article-1-717-en.html
Abstract:   (1993 Views)
Abstract
The effects of perfluorocarbon (PFC) on paraquat (PQ) induced acute lung injury (ALI) was evaluated among rats. Twenty four Wistar rats were divided into 4 groups: control group injected by saline physiologic 0.9%, PFC group injected by Perfluorocarbon, PQ group injected by PQ and PQ+PFC group injected by PFC one hour after receiving paraquat. Bronchoalveular fluid content, inflammatory cytokines, oxidative and histopathologic changes were measured after 72h. The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1(TGF-β1) in the PQ group were increased compared to either control or PFC groups, but their levels decreased in PQ+PFC group significantly (p<0.05). Also, histopathologic evaluation revealed an increase in malondialdehyde (MDA) and hydroxyproline (HP) in the PQ group but a decrease in PQ+PFC group significantly (p<0.01). PFC emulsion by its anti-inflammatory, anti-oxidative and anti-fibrotic properties can reduce the inflammatory and fibrotic alterations, pulmonary oedema, and pulmonary histopathologic changes created by PQ.
     
: Cross sectional | Subject: General
Received: 2015/03/25 | Accepted: 2015/05/19 | Published: 2019/11/15

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