Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.Mast cells and microvessel play an important role in tumor development and progression through angiogenesis. Because of
the more aggressive potential and poor prognosis of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous
cell carcinoma (CSCC), the aim of the present study was to compare of density of mast cells and microvessel between in
oral and cutaneous squamous cell carcinoma. In this study cross-sectional study, we performed an immuno histochemical
analysis in 100 paraffin blocks that included 40 cases of OSCC and 40 CSCC and 20 cases of normal skin and normal oral
mucosa. Mast cells and microvascular density were stained by mast cell tryptase and immunohistochemistry assay using
CD34. Statistical analyses were performed in SPSS 16 software. There was a significant statistical correlation (*P<0.05)
between mast cell concentration and microvascular density in OSCC and CSCC compared to control groups. In OSCC the
mast cell concentration and microvascular density were significantly higher (*P<0.05) compared with the CSCC. Therefore,
according findings present study, mast cell concentration and microvascular density may be used as a factor for detecting
the progression, malignant potential and invasion of OSCC compared to CSCC.

Keywords: Key words: Squamous cell carcinoma, Mast cell, Microvessel, Prognosis