Volume 1, Issue 4 (3-2019)                   2019, 1(4): 0-0 | Back to browse issues page

Ethics code: Ir.Medilam.Rec.1396.32

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Abbasi N. Protective effect of Smyrnium cordifolium essential oil and its active ingredient on pentylenetetrazole-induced seizures in mice. Journal title 2019; 1 (4)
URL: http://newresearch.medilam.ac.ir/article-1-332-en.html
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical sciences, Ilam, Iran
Abstract:   (1595 Views)
Anticonvulsant activity in a dose-dependent manner in the PTZ model. Applies.
However, our findings showed that Kurzen, the bioactive fraction of the essential oil, was stronger than SCEO as an anticonvulsant, as these compounds appear to be effective on PTZ-induced seizures, which seems to be effective for seizures. Humans are also effective (1), although the properties of other species of the Apiaceae family have been reported against PTZ-induced seizures. Olive oil (1-3 ml / kg) has been reported to delay seizure attacks (2). Therefore, SCEO and curzerene appear to cause less toxic effects than PTZ. Seizures of other essential oils have been studied. SECO phytochemical analysis confirmed the presence of terpenoids, anticoagulant activity Therefore, terpenoids may be part of the SCEO anticonvulsant action through various mechanisms (3). Terpenoids and plants containing these compounds have anticonvulsant properties. However, tumor growth has been shown to be significantly inhibited in naked SPC-A1 cell mice using Korzen at a dose of 135 mg / kg (4). In the present study, Kurzen at a dose of 0.2 mg / kg only prolongs the onset of seizures compared with the control group. It is noteworthy that the anticonvulsant effect in the present study started from 0.2 mg / kg and was less than the effective dose of SCEO (200 mg / kg). This evidence suggests that curzerene identified in the Smyrnium Cordifolium study may be partly responsible for anticonvulsant activity.
There is a hypothesis that SCEO and curzerene can activate kappa opioid receptors (KORs) and produce a protective effect against PTZ-induced seizures. The anticonvulsant activity of KOR agonists has been extensively developed by previous animal studies (5). This study showed some evidence for the anticoagulant activities of SCEO and curzerene in the diagnosis of the PTZ model in mice.
Due to the protective effects of SCEO and Kurzen on classical seizures, they can be useful for the treatment of short-term seizures.
: Cross sectional | Subject: General
Received: 2019/04/7 | Accepted: 2019/08/9 | Published: 2019/03/1

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