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Ethics code: IR.MEDILAM. REC.1397.85
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abbasi N, aidy A. Title:Antioxidant and hepatoprotective of Allium Latifolium extract against CCL4 induced damage in Rat. Journal title 2024; 1403 (1)
URL: http://newresearch.medilam.ac.ir/article-1-2939-en.html
URL: http://newresearch.medilam.ac.ir/article-1-2939-en.html
biotechnology and medicinal plants
Abstract: (12 Views)
Hepatoxicity is a common complication of acetaminophen. This study was to evaluate the effects of Nectaroscordum tripedale
extract (NTE) and its bioactive component tetramethylpyrazine (TMP) on acetaminophen-induced liver failure. The
presence of TMP in NTE was determined by HPLC. The hepatoprotective effect of NTE and TMP (50, 100 and 200 mg/
kg, respectively) was evaluated by the assay of liver function parameters; total bilirubin, alanine aminotransaminase (ALT),
aspartate aminotransaminase (AST), alkaline phosphatase activities (ALP) and superoxide dismutase (SOD). Results revealed
that TMP was 1.24 mg/g in NTE. LD50
of the NTE and TMP was 3800 mg/kg and 2700 mg/kg, respectively. NTE and TMP
(100 and 200 mg/kg) decreased the ALT, AST, ALP, and bilirubin but the SOD increased in a dose-dependent manner in
acetaminophen-induced liver failure rats. In conclusion, NTE and its fraction TMP may be a protecting liver candidate against
acetaminophen-induced hepatotoxicity.
extract (NTE) and its bioactive component tetramethylpyrazine (TMP) on acetaminophen-induced liver failure. The
presence of TMP in NTE was determined by HPLC. The hepatoprotective effect of NTE and TMP (50, 100 and 200 mg/
kg, respectively) was evaluated by the assay of liver function parameters; total bilirubin, alanine aminotransaminase (ALT),
aspartate aminotransaminase (AST), alkaline phosphatase activities (ALP) and superoxide dismutase (SOD). Results revealed
that TMP was 1.24 mg/g in NTE. LD50
of the NTE and TMP was 3800 mg/kg and 2700 mg/kg, respectively. NTE and TMP
(100 and 200 mg/kg) decreased the ALT, AST, ALP, and bilirubin but the SOD increased in a dose-dependent manner in
acetaminophen-induced liver failure rats. In conclusion, NTE and its fraction TMP may be a protecting liver candidate against
acetaminophen-induced hepatotoxicity.
Subject:
General
Received: 2024/12/18 | Accepted: 2024/05/30 | Published: 2024/05/30
Received: 2024/12/18 | Accepted: 2024/05/30 | Published: 2024/05/30
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