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Jafarpour M. Effect of Ketofol on Pain and Complication after Caesarean Delivery under Spinal Anaesthesia: A Randomized Double-blind Clinical Trial. Journal title 2018; 1 (1)
URL: http://newresearch.medilam.ac.ir/article-1-255-en.html
URL: http://newresearch.medilam.ac.ir/article-1-255-en.html
Department of Midwifery, School of Nursing and Midwifery, Ilam University of Medical sciences, Ilam, Iran
Abstract: (2940 Views)
ABSTRACT
Introduction: Pain is the key concern of women after caesarean
delivery that may interfere with breastfeeding.
Aim: The aim of this study was to assess effect of ketofol
(ketamine/propofol combination) on pain and complication after
caesarean delivery under spinal anaesthesia.
Materials and Methods: In this randomized double-blind
clinical trial, 92 parturient scheduled for elective caesarean
delivery under spinal anaesthesia were included. The simple
random sampling method was used to place subjects in four
groups of ketamine (0.25 mg/kg), propofol (0.25 mg/kg), ketofol
(25 mg ketamine plus 25 mg propofol) and placebo (saline).
The drugs were administered intravenously immediately after
clamping the umbilical cord. Visual Analog Scale (VAS) was used
to determine the intensity of pain. Complications after surgery
including shivering, nausea and vomiting as well as onset of
breastfeeding were recorded.
Results: The mean score of pain, morphine consumption and
time of breastfeeding in the ketofol group were significantly
lower than other groups at various intervals (p<0.05, p<0.001).
The frequencies of shivering, nausea, vomiting,
retention and
pruritus in the ketofol group were significantly
lower than other
groups (p<0.001, p<0.05)
Conclusion: The effective role of ketofol on reducing pain and
complication after caesarean delivery indicated that it can be
considered as a safe and alternative drug in these patients.
Introduction: Pain is the key concern of women after caesarean
delivery that may interfere with breastfeeding.
Aim: The aim of this study was to assess effect of ketofol
(ketamine/propofol combination) on pain and complication after
caesarean delivery under spinal anaesthesia.
Materials and Methods: In this randomized double-blind
clinical trial, 92 parturient scheduled for elective caesarean
delivery under spinal anaesthesia were included. The simple
random sampling method was used to place subjects in four
groups of ketamine (0.25 mg/kg), propofol (0.25 mg/kg), ketofol
(25 mg ketamine plus 25 mg propofol) and placebo (saline).
The drugs were administered intravenously immediately after
clamping the umbilical cord. Visual Analog Scale (VAS) was used
to determine the intensity of pain. Complications after surgery
including shivering, nausea and vomiting as well as onset of
breastfeeding were recorded.
Results: The mean score of pain, morphine consumption and
time of breastfeeding in the ketofol group were significantly
lower than other groups at various intervals (p<0.05, p<0.001).
The frequencies of shivering, nausea, vomiting,
retention and
pruritus in the ketofol group were significantly
lower than other
groups (p<0.001, p<0.05)
Conclusion: The effective role of ketofol on reducing pain and
complication after caesarean delivery indicated that it can be
considered as a safe and alternative drug in these patients.
: Cross sectional |
Subject:
General
Received: 2015/04/21 | Accepted: 2015/06/7 | Published: 2018/09/29
Received: 2015/04/21 | Accepted: 2015/06/7 | Published: 2018/09/29
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