Volume 5, Issue 4 (3-2023)
2023, 5(4): 0-0 |
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Ethics code: IR.MEDILAM.REC.1396.90
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Moayeri A, Ghasemi Hamidabadi H, Darvishi M. Transdifferentiation of the human umblical cord-derived mesenchymal stem cells to dopaminergic neuron on conductive hydrogel. Journal title 2023; 5 (4)
URL: http://newresearch.medilam.ac.ir/article-1-2160-en.html
URL: http://newresearch.medilam.ac.ir/article-1-2160-en.html
Department of Anatomical Sciences, School of Medicine, Ilam University of Medical sciences, Ilam, Iran
Abstract: (909 Views)
Parkinson's disease (PD) is one of the most common disorders related to the destruction of the central nervous system, which affects almost one percent of people over 50 years old. Parkinson's disease is a neurodegenerative disease that results from the gradual loss of dopaminergic neurons in the substantia nigra of the midbrain. In the clinic, this disease is characterized by movement symptoms such as muscle stiffness, tremors at rest, slowness of movement and walking. Also, other symptoms such as impaired consciousness, memory and perception are also symptoms of Parkinson's Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) are one of the cells that have the potential to multiply and differentiate into other cells, including neurons (13,14). These cells can be used as an ideal source in regenerative processes due to easy access, rapid expansion in the culture medium and long-term survival in the host tissue. In addition, the mentioned cells have low immunogenicity, similar to bone marrow mesenchymal stem cells, and due to their low tumorigenic properties, they seem to be a suitable option for allogeneic transplantation. Therefore, in this study, this cell source is used for differentiation and production. Dopaminergic functional cell is used. In addition, other studies indicate that mesenchymal stem cells derived from the human umbilical cord have differentiating power towards fat, cartilage, bone and other cell lines and are also able to stimulate the nerve process through inducing substances. undergo transdifferentiation in invitro and in vivo environments and move towards nerve and glial cells
Received: 2020/12/2 | Accepted: 2021/02/14 | Published: 2023/03/1
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