Volume 5, Issue 4 (3-2023)
2023, 5(4): 0-0 |
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Ethics code: IR.MEDILAM.REC.1400.204
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Shams M, Naserifar R, Majidiani H, Asghari A. Determination of Toxoplasma gondii Tyrosine-rich oocyst wall protein by computer methods. Journal title 2023; 5 (4)
URL: http://newresearch.medilam.ac.ir/article-1-1511-en.html
URL: http://newresearch.medilam.ac.ir/article-1-1511-en.html
Zoonotic Diseases Research Center, Ilam University of Medical sciences, Ilam, Iran
Abstract: (382 Views)
Toxoplasmosis due to Toxoplasma gondii is a global threat with significant zoonosis. This parasite has two final hosts (cats) and intermediates (a wide range of warm-blooded animals). The most important complication of abortion parasites in pregnant women and domestic animals such as sheep and pigs, although in people with weakened immune system the disease occurs in the form of pneumonia (pneumonia) or brain (encephalitis). The parasite has three pathogenic forms for humans, each of which plays a major role in the epidemiology and transmission of the disease: oocysts (contaminated water and food), tachyzoites (congenital or through blood transfusions), and bradycosites (transmission through organ donation or meat products). (Infected with tissue cysts).
More than 30 years have passed since the Toxoplasma vaccine study, but the commercial vaccine for humans has not yet reached the production stage.Killed or attenuated vaccines have not received much attention today in terms of human immunity or immunizing power in the body, but on the other hand, subunit vaccines are of interest to researchers. These vaccines include DNA vaccines or protein vaccines, which often work together with an adjuvant or helper to produce an appropriate immune response against the parasite.
In this way, antigens from many different stages of the parasite's life have been identified and evaluated to assess immunization, including surface antigens (SAGs), and organ antigens in tachyzoites and brady zoites such as microns (MICs). , ROP (Dop) and Dense Granules (GRA). Since fewer studies have been performed on parasites related to the parasite oocyte wall, we decided to conduct the present bioinformatics study on Toxoplasma gondii oocyte tyrosine-rich antigen (TrOWP).
Received: 2021/06/9 | Accepted: 2021/11/20 | Published: 2023/03/4
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