Parasites are a group of micro-organisms that have evolved enough with at least one host larger than themselves to complete their evolution and meet nutritional and reproductive needs.They are constantly exploring and confronting the host's immune system to ensure their survival and complete their life cycle.In this context, a variety of molecules are expressed and used both by the host and by the invading parasite to confront each other. With the increasing progress of biochemical methods and molecular biology, it has been determined that some of these molecules, in addition to their toxic or harmful role, can be immune-modulating roles, and therefore, they may be used for the possible treatment of various immune-mediated disorders or atopic diseases. According to the hypothesis of the World Health Organization, which was proposed in 1989, exposure to infectious agents during childhood has an inverse correlation with the occurrence of allergic diseases in the later years of a person's life, similar to what we see in developed countries. This issue was then extended to inflammatory diseases, type 1 diabetes and cancer.Regarding parasites, recently, in addition to the carcinogenic role of some of them such as Schistosoma hematobium and Trichomonas vaginalis, studies have been published to show the anti-cancer properties of some compounds derived from parasites.Therefore, the purpose of the present systematic review is to systematically collect these articles and extract valuable data from them in order to advance future approaches and also identify possible weaknesses.