Volume 5, Issue 3 (12-2022)
2022, 5(3): 0-0 |
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Ethics code: IR.MEDILAM.REC.1399.332
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Ahmadi I, Maleki M, Kafashian M, Falahi S, Kenarkoohi A, Ghanei Alvar H, et al . Study of Comparative changes in blood cortisol concentration and ACTH in COVID-19 patients admitted to Shahid Mostafa Khomeini Hospital in Ilam and Shahid Mohammadi Hospital in Bandar Abbas. Journal title 2022; 5 (3)
URL: http://newresearch.medilam.ac.ir/article-1-1238-en.html
URL: http://newresearch.medilam.ac.ir/article-1-1238-en.html
Iraj Ahmadi 
, Maryam Maleki , Mohamadreza Kafashian , Shahab Falahi , Azra Kenarkoohi , Hori Ghanei Alvar , Hmideh Estabargh nia , Mehdi Hassani Azad , Amin Ghanbarnejad , Mitra Kazemi Jahromi
, Maryam Maleki , Mohamadreza Kafashian , Shahab Falahi , Azra Kenarkoohi , Hori Ghanei Alvar , Hmideh Estabargh nia , Mehdi Hassani Azad , Amin Ghanbarnejad , Mitra Kazemi Jahromi
Department of Physiology, School of Medicine, Ilam University of Medical sciences, Ilam, Iran
Abstract: (815 Views)
Physiological stress caused by diseases increases cortisol by acting on the hypothalamic-pituitary-adrenal axis. Elevated cortisol is one of the most important mechanisms for overcoming stress, which triggers adaptive mechanisms in the cardiovascular system, metabolism, and immune system. The effect of COVID-19 on blood cortisol is unclear. SARS-CoV-2 appears to initiate immunological responses that theoretically increase morbidity and mortality, possibly due to cortisol secretion failure. Not many studies have been done on this. Whether this trend may be related to the pathophysiology of COVID-19 is not yet known, and there is insufficient evidence of adrenal changes in patients dying from SARS-CoV-2, but in patients with SARS-CoV, monocyte infiltration has been observed. There are lymphocytes and focal necrosis in the adrenal glands. Venous vasculitis has also been reported in the medulla. Due to the similarities between the two viruses, these adrenal disorders may also be seen in COVID 19 disease patients.
Received: 2020/10/31 | Accepted: 2022/06/19 | Published: 2022/12/20
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