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Anvari E, Sayehmiri K. assessment of swimming on expression of mirna-133 erk mek and igf1 genes in the heart tissue of diabetic ovariectomized rats. Journal title 2020; 3 (1)
URL: http://newresearch.medilam.ac.ir/article-1-1074-en.html
URL: http://newresearch.medilam.ac.ir/article-1-1074-en.html
Department of Physiology, School of Medicine, Ilam University of Medical sciences, Ilam, Iran
Abstract: (2403 Views)
and fibrosis in ovariectomized type 2 diabetic (T2DM) rats (OVR.D) is well known. The current
study aimed to investigate the simultaneous effects of T2DM and swimming plan on the expression
of some apoptotic, anti-apoptotic biomarkers and glycogen changes in the cardiac muscle tissue of
ovariectomized (OVR) rats.
Materials and Methods: Forty rats were randomly sorted into 4 equal categories; sham, OVR, OVR.D
and diabetic ovariectomized with an 8 week of swimming plan (OVR.D.E). Lipid profile and miR-133,
Bcl-2, Bax, caspase-3 and caspase-8 levels were evaluated in the cardiac tissue.
Results: Ovariectomy significantly (P-value<0.05) increased cholesterol, triglyceride, LDL, Bax, caspase-3,
caspase-8 and decreased (P-value<0.05) HDL, miR-133, Bcl-2 in the cardiac tissue and a further reduction
in the expression of miR-133, Bcl-2 and an enhancement in Bax, caspase-3 and caspase-8 in OVR.D
rats was observed (P-value<0.01). However, exercise training significantly reversed all the measured
parameters (P-value<0.05). Also, exercise training improved abnormal tissue structure, fragmentation
and irregular form of glycogen granules in the OVR.D.E compared to OVR and OVR.D animals.
Conclusion: Exercise training could prevent the cardiac disturbance, enhance the expression of antiapoptotic
markers and decrease apoptotic biomarkers in the hearts of OVR.D animals. Therefore,
based on the findings of this study suggested using the exercise’s beneficial effects for prevention of
the cardiac cell death in OVR.D animals.
study aimed to investigate the simultaneous effects of T2DM and swimming plan on the expression
of some apoptotic, anti-apoptotic biomarkers and glycogen changes in the cardiac muscle tissue of
ovariectomized (OVR) rats.
Materials and Methods: Forty rats were randomly sorted into 4 equal categories; sham, OVR, OVR.D
and diabetic ovariectomized with an 8 week of swimming plan (OVR.D.E). Lipid profile and miR-133,
Bcl-2, Bax, caspase-3 and caspase-8 levels were evaluated in the cardiac tissue.
Results: Ovariectomy significantly (P-value<0.05) increased cholesterol, triglyceride, LDL, Bax, caspase-3,
caspase-8 and decreased (P-value<0.05) HDL, miR-133, Bcl-2 in the cardiac tissue and a further reduction
in the expression of miR-133, Bcl-2 and an enhancement in Bax, caspase-3 and caspase-8 in OVR.D
rats was observed (P-value<0.01). However, exercise training significantly reversed all the measured
parameters (P-value<0.05). Also, exercise training improved abnormal tissue structure, fragmentation
and irregular form of glycogen granules in the OVR.D.E compared to OVR and OVR.D animals.
Conclusion: Exercise training could prevent the cardiac disturbance, enhance the expression of antiapoptotic
markers and decrease apoptotic biomarkers in the hearts of OVR.D animals. Therefore,
based on the findings of this study suggested using the exercise’s beneficial effects for prevention of
the cardiac cell death in OVR.D animals.
: Cross sectional |
Subject:
General
Received: 2016/06/25 | Accepted: 2016/08/2 | Published: 2020/05/30
Received: 2016/06/25 | Accepted: 2016/08/2 | Published: 2020/05/30
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